Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 8/20 | 0.62 |
| ▸ | MERTK | Q12866 | 5/20 | 0.62 |
| ▸ | MET | P08581 | 8/20 | 0.58 |
| ▸ | KDR | P35968 | 7/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.52 |
| ▸ | LYN | P07948 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | HCK | P08631 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371760 | 0.92 | KDR (0.67) | AXLMERTKMETKDRPDGFRA | |
| SCHEMBL1890654 | 0.84 | PDGFRA (0.79) | AXLMERTKMETKDRPDGFRA | |
| SCHEMBL371709 | 0.81 | KDR (0.62) | AXLMERTKMETKDRPDGFRA | |
| SCHEMBL371648 | 0.81 | PDGFRA (0.84) | AXLMERTKMETKDRPDGFRA | |
| SCHEMBL12444758 | 0.80 | MET (0.89) | AXLMERTKMETKDRPDGFRA | |
| SCHEMBL30314058 | 0.79 | MET (0.83) | AXLMERTKMETKDRPDGFRA | |
| SCHEMBL371549 | 0.79 | AXL (0.67) | AXLMERTKMETKDRPDGFRA | |
| SCHEMBL371630 | 0.79 | MET (0.83) | AXLMERTKMETKDRPDGFRA | |
| SCHEMBL4401175 | 0.79 | MET (0.76) | AXLMERTKMETKDRPDGFRA | |
| SCHEMBL23911835 | 0.78 | AXL (0.84) | AXLMERTKMETKDRAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2392564-A1 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2011-12-07 | — | — | EP | disclosed |