Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.46 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 2/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 5/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12127741 | 0.83 | APP (0.56) | APPTTBK1TTBK2MEN1KMT2A | |
| SCHEMBL416002 | 0.83 | APP (0.52) | APPTTBK1TTBK2GAAMEN1 | |
| SCHEMBL14147414 | 0.83 | APP (0.52) | APPAURKATTBK1TTBK2DHFR | |
| SCHEMBL412949 | 0.83 | APP (0.52) | APPTTBK1TTBK2DHFRGAA | |
| SCHEMBL721045 | 0.82 | APP (0.55) | APPAURKATTBK1TTBK2DHFR | |
| SCHEMBL12128989 | 0.81 | APP (0.56) | APPRIPK1TYRMAPK1AXL | |
| SCHEMBL12288172 | 0.81 | HDAC6 (0.58) | APPTTBK1TTBK2MEN1KMT2A | |
| SCHEMBL417443 | 0.79 | APP (0.49) | APPAURKATNIKGAANPSR1 | |
| SCHEMBL411431 | 0.79 | RAB9A (0.57) | APPTTBK1TTBK2DHFRGAA | |
| SCHEMBL12128995 | 0.78 | APP (0.67) | APPTYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2395004-A2 | PYRROLO [2,3-B]PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2011-12-14 | — | — | EP | disclosed |