Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 3/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.51 |
| ▸ | CDK9 | P50750 | 2/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.51 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.51 |
| ▸ | FYN | P06241 | 6/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1203165 | 0.91 | MKNK1 (0.49) | CCNA2CDK2DYRK3CCNT1CDK9 | |
| SCHEMBL1203922 | 0.90 | PIM1 (0.46) | CCNA2CDK2DYRK3CCNT1CDK9 | |
| SCHEMBL1203006 | 0.88 | ALDH1A1 (0.42) | CCNA2CDK2DYRK3CCNT1CDK9 | |
| SCHEMBL1202773 | 0.87 | FYN (0.51) | FYNKCNH2MKNK1MEN1KMT2A | |
| SCHEMBL1202366 | 0.87 | DYRK3 (0.49) | CCNA2CDK2DYRK3CCNT1CDK9 | |
| SCHEMBL1203131 | 0.86 | FYN (0.53) | FYNMKNK1IRAK4ALDH1A1TP53 | |
| SCHEMBL1202745 | 0.82 | MKNK1 (0.56) | CCNA2CDK2DYRK3CCNT1CDK9 | |
| SCHEMBL2905619 | 0.82 | KCNH2 (0.47) | CCNA2CDK2DYRK3CCNT1CDK9 | |
| SCHEMBL1203230 | 0.80 | ESR1 (0.54) | CCNA2CDK2DYRK3CCNT1CDK9 | |
| SCHEMBL1202750 | 0.80 | NPC1 (0.54) | CCNA2CDK2DYRK3CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046127-A1 | Imidazopyridazines for Use as Protein Kinase Inhibitors | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046127-A1 | Imidazopyridazines for Use as Protein Kinase Inhibitors | PIM1, PIM3, PIM2 | CCNA2 819/4885CDK2 54/4885DYRK3 481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.