SCHEMBL120408

SCHEMBL120408

O=C(NCC(C(=O)O)c1ccccc1)OCC1c2ccccc2-c2ccccc21

nearest known ligand 0.56

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.56
EPHX2 P34913 1/20 0.48
MDM4 O15151 2/20 0.46
TP53 P04637 2/20 0.46
CASP3 P42574 2/20 0.46
FABP7 O15540 2/20 0.44
FABP5 Q01469 2/20 0.44
TLR2 O60603 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25173357 1.00 KMT2A (0.56) KMT2AEPHX2MDM4TP53CASP3
SCHEMBL5917388 0.92 KMT2A (0.51) KMT2AEPHX2MDM4TP53CASP3
SCHEMBL6731866 0.86 KMT2A (0.57) KMT2AEPHX2CASP3FABP7FABP5
SCHEMBL6443477 0.85 KMT2A (0.49) KMT2AEPHX2CASP3
SCHEMBL29368747 0.84 KMT2A (0.58) KMT2AEPHX2MDM4TP53CASP3
SCHEMBL1764428 0.84 KMT2A (0.58) KMT2AEPHX2MDM4TP53CASP3
SCHEMBL31010836 0.84 KMT2A (0.58) KMT2AEPHX2MDM4TP53CASP3
SCHEMBL31714178 0.84 KMT2A (0.58) KMT2AEPHX2MDM4TP53CASP3
SCHEMBL2654395 0.84 KMT2A (0.58) KMT2AEPHX2MDM4TP53CASP3
SCHEMBL31536519 0.84 KMT2A (0.58) KMT2AEPHX2MDM4TP53CASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12281149-B2 Modulators of G-protein coupled receptors CARMOT THERAPEUTICS, INC. (US) 2025-04-22 US disclosed
US-20240383960-A1 Modulators of G-Protein Coupled Receptors CARMOT THERAPEUTICS INC. (US) 2024-11-21 US disclosed
WO-2024110757-A1 CONTROL OF NANOCAGE SELF-ASSEMBLY KING'S COLLEGE LONDON (GB) 2024-05-30 WO disclosed
CN-117980325-A Modulators of G-protein coupled receptors 卡莫特治疗学股份有限公司 2024-05-03 CN disclosed
US-20240117006-A1 MODIFIED INTEGRIN POLYPEPTIDES, MODIFIED INTEGRIN POLYPEPTIDE DIMERS, AND USES THEREOF THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 2024-04-11 US disclosed
EP-4337682-A2 MODULATORS OF G-PROTEIN COUPLED RECEPTORS Carmot Therapeutics Inc. (US) 2024-03-20 EP disclosed
US-20230151074-A1 MODULATORS OF G-PROTEIN COUPLED RECEPTORS CARMOT THERAPEUTICS, INC. 2023-05-18 US disclosed
WO-2022241287-A2 MODULATORS OF G-PROTEIN COUPLED RECEPTORS CARMOT THERAPEUTICS, INC. (US) 2022-11-17 WO disclosed
US-20220195017-A1 PATHOGEN BINDING METHODS AND COMPOSITIONS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2022-06-23 US disclosed
US-11021709-B2 Lin28/let-7 crystal structures, purification protocols, and molecular probes suitable for screening assays and therapeutics PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2021-06-01 US disclosed
WO-2013071049-A1 GRAMICIDIN A MUTANTS THAT FUNCTION AS ANTIBIOTICS WITH IMPROVED SOLUBILITY AND REDUCED TOXICITY TRUSTEES OF BOSTON COLLEGE (US) 2013-05-16 WO disclosed
EP-2582715-A2 GROWTH HORMONE SECRETATOGUE RECEPTOR ANTAGONISTS AND USES THEREOF The Administrators of the Tulane Educational Fund (US) 2013-04-24 EP disclosed
US-20130064895-A1 Amphiphilic Peptides and Peptide Particles PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2013-03-14 US disclosed
WO-2013028843-A1 PEPTIDE NANOPARTICLES AND USES THEREOF PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2013-02-28 WO disclosed
WO-2012177986-A2 CONJUGATE-BASED ANTIFUNGAL AND ANTIBACTERIAL PRODRUGS VYOME BIOSCIENCES (IN) 2012-12-27 WO disclosed
US-20120058428-A1 PATTERNING PROCESS AND RESIST COMPOSITION SHIN-ETSU CHEMICAL CO., LTD. (JP) 2012-03-08 US disclosed
US-20120058428-A1 PATTERNING PROCESS AND RESIST COMPOSITION SHIN-ETSU CHEMICAL CO., LTD. (JP) 2012-03-08 US disclosed
WO-2011159917-A2 GROWTH HORMONE SECRETATOGUE RECEPTOR ANTAGONISTS AND USES THEREOF THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) 2011-12-22 WO disclosed
EP-0800516-B1 FIBRINOGEN RECEPTOR ANTAGONISTS HAVING SUBSTITUTED (b)-AMINO ACID RESIDUES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME NIPPON STEEL CORP (JP) 2001-09-19 EP disclosed
US-5866592-A Fibrinogen receptor antagonist and pharmaceutical compositions comprising the same NIPPON STEEL CORPORATION (JP) 1999-02-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240383960-A1 Modulators of G-Protein Coupled Receptors GIPR, GLP1R, GCGR KMT2A 2726/4885EPHX2 3706/4885MDM4 4625/4885
US-20240117006-A1 MODIFIED INTEGRIN POLYPEPTIDES, MODIFIED INTEGRIN POLYPEPTIDE DIMERS, AND USES THEREOF ITGA2B, ITGB1, ITGA1 KMT2A 4350/4885EPHX2 1788/4885MDM4 4361/4885
US-12281149-B2 Modulators of G-protein coupled receptors GIPR, GLP1R, GCGR KMT2A 2726/4885EPHX2 3721/4885MDM4 4636/4885
US-20230151074-A1 MODULATORS OF G-PROTEIN COUPLED RECEPTORS GIPR, GLP1R, GCGR KMT2A 2726/4885EPHX2 3721/4885MDM4 4636/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.