Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23887607 | 0.84 | SYK (0.42) | SYKTGFBR1KCNH2SCN9AROCK1 | |
| SCHEMBL15273403 | 0.81 | ROCK1 (0.53) | KCNH2SCN9AROCK1HTR3EHTR3B | |
| SCHEMBL12143475 | 0.81 | PIK3C3 (0.43) | ITKJAK2TYK2 | |
| SCHEMBL30353144 | 0.78 | LYN (0.39) | SYKROCK1ITKIGF1RAURKA | |
| SCHEMBL1272593 | 0.78 | — | — | |
| SCHEMBL31512367 | 0.77 | MALT1 (0.49) | — | |
| SCHEMBL12141964 | 0.77 | IGF1R (0.33) | SYKITKIGF1RAURKANPC1 | |
| SCHEMBL31512372 | 0.77 | ROCK1 (0.35) | TGFBR1ROCK1ITKNPC1MAPT | |
| SCHEMBL12775454 | 0.77 | SYK (0.38) | SYKITKIGF1RNPC1MAPT | |
| SCHEMBL342602 | 0.75 | RAB9A (0.39) | IGF1RNPC1MAPTMAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382230-B2 | Methods and compositions for modulating Ire1, SRC and ABL activity | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-07-05 | — | — | US | disclosed |
| US-20150011575-A1 | METHODS AND COMPOSITIONS FOR MODULATING IRE1, SRC, AND ABL ACTIVITY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-01-08 | — | — | US | disclosed |
| US-8815885-B2 | Methods and compositions for modulating IRE1, SRC, and ABL activity | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-08-26 | — | — | US | disclosed |
| US-20110319436-A1 | Methods and Compositions for Modulating IRE1, SRC, and ABL Activity | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150011575-A1 | METHODS AND COMPOSITIONS FOR MODULATING IRE1, SRC, AND ABL ACTIVITY | XBP1, SRC, HSP90B1 | SYK 124/4885TGFBR1 4205/4885KCNH2 4357/4885 |
| US-20110319436-A1 | Methods and Compositions for Modulating IRE1, SRC, and ABL Activity | XBP1, SRC, HSP90B1 | SYK 124/4885TGFBR1 4205/4885KCNH2 4357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.