⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1040746 | 0.84 | NOTUM (0.32) | — | |
| SCHEMBL2852145 | 0.84 | NOTUM (0.32) | — | |
| SCHEMBL3861670 | 0.82 | — | — | |
| SCHEMBL170375 | 0.82 | — | — | |
| SCHEMBL4439651 | 0.80 | — | — | |
| Water SCHEMBL2643978 | 0.80 | HCAR2 (0.41) | — | |
| Hydrochloric Acid SCHEMBL4575106 | 0.78 | — | — | |
| SCHEMBL11677933 | 0.77 | — | — | |
| SCHEMBL1666899 | 0.77 | ALDH1A1 (0.34) | — | |
| SCHEMBL15555569 | 0.77 | BAZ2B (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4632993-A | Process for making 2-guanidino-4-(2-methyl-4-imidazolyl) thiazole dihydrobromide | PFIZER INC. (US) | 1986-12-30 | — | — | US | claimed |
| CN-85107520-A | The preparation method of 2-guanidine radicals-4-(2-methyl-4-imidazolyl) thiazole dihydrogen bromide | — | 1986-07-23 | — | — | CN | claimed |
| EP-0178123-A2 | 2-Guanidino-4-(2-methyl-4-imidazolyl)thiazole dihydrobromide and process therefor | PFIZER INC. (US) | 1986-04-16 | — | — | EP | claimed |
| EP-3441394-B1 | STEM CELL CULTURES | SCRIPPS RESEARCH INST (US) | 2020-01-29 | — | — | EP | disclosed |
| EP-3103804-B1 | STEM CELL CULTURES | SCRIPPS RESEARCH INST (US) | 2019-01-30 | — | — | EP | disclosed |
| CN-108780072-A | Charged mass marking system | 普度研究基金会 | 2018-11-09 | — | — | CN | disclosed |
| US-9834542-B2 | LXR modulators | BRISTO-MYERS SQUIBB COMPANY (US) | 2017-12-05 | — | — | US | disclosed |
| US-9834542-B2 | LXR modulators | BRISTO-MYERS SQUIBB COMPANY (US) | 2017-12-05 | — | — | US | disclosed |
| EP-2968275-B1 | LXR MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2017-11-29 | — | — | EP | disclosed |
| EP-2968275-B1 | LXR MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2017-11-29 | — | — | EP | disclosed |
| EP-3208269-A1 | INHIBITORS OF C-FMS KINASE | Janssen Pharmaceutica N.V. (BE) | 2017-08-23 | — | — | EP | disclosed |
| EP-0156644-A1 | Process and intermediates for 4-acetylimidazoles | PFIZER INC. (US) | 1985-10-02 | — | — | EP | disclosed |
| US-4510313-A | 2-Guanidino-4-heteroarylthiazoles | PFIZER INC. (US) | 1985-04-09 | — | — | US | disclosed |
| EP-0050458-B1 | 2-GUANIDINO-4-HETEROARYLTHIAZOLES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER INC. (US) | 1985-01-02 | — | — | EP | disclosed |
| EP-0125777-A1 | Process and intermediates for preparation of 4-acetyl-2-substituted-imidazoles | PFIZER INC. (US) | 1984-11-21 | — | — | EP | disclosed |
| US-4482723-A | FORM 3-HALO-4,4-DIALKOXY-2-ALKANONE AND AN AMIDINE | PFIZER INC. (US) | 1984-11-13 | — | — | US | disclosed |
| EP-0116205-A1 | 4(5)-Acetyl-2-methylimidazole process | PFIZER INC. (US) | 1984-08-22 | — | — | EP | disclosed |
| US-4452987-A | Haloacetyl imidazoles | PFIZER INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4374843-A | 2-Guanidino-4-heteroarylthiazoles | PFIZER INC. (US) | 1983-02-22 | — | — | US | disclosed |
| EP-0050458-A2 | 2-Guanidino-4-heteroarylthiazoles and pharmaceutical compositions containing them | PFIZER INC. (US) | 1982-04-28 | — | — | EP | disclosed |