Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | CDK1 | P06493 | 4/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12060325 | 0.90 | HSP90AA1 (0.35) | GAAMEN1KMT2AALOX12ALOX15 | |
| SCHEMBL1149360 | 0.85 | MEN1 (0.38) | GAAMEN1KMT2ACDK1CCNB2 | |
| SCHEMBL14609785 | 0.78 | MEN1 (0.34) | GAAMEN1KMT2AALOX12ALOX15 | |
| SCHEMBL16541250 | 0.76 | KDM4E (0.44) | GAAMEN1KMT2ACDK1CCNB2 | |
| SCHEMBL14525272 | 0.75 | CCNB2 (0.35) | GAAMEN1KMT2ACDK1CCNB2 | |
| SCHEMBL12908774 | 0.75 | CCNB2 (0.35) | GAAMEN1KMT2ACDK1CCNB2 | |
| SCHEMBL1148744 | 0.74 | MEN1 (0.42) | GAAMEN1KMT2AALOX12ALOX15 | |
| SCHEMBL1148187 | 0.74 | MEN1 (0.40) | GAAMEN1KMT2AALOX12ALOX15 | |
| SCHEMBL1147887 | 0.73 | MEN1 (0.44) | GAAMEN1KMT2AALOX12ALOX15 | |
| SCHEMBL1343875 | 0.73 | GAA (0.39) | GAAMEN1KMT2AALOX12ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9101614-B2 | Method for treating non-Hodgkin's lymphoma | SYNTA PHARMACEUTICALS CORP. (US) | 2015-08-11 | — | — | US | disclosed |
| US-9101614-B2 | Method for treating non-Hodgkin's lymphoma | SYNTA PHARMACEUTICALS CORP. (US) | 2015-08-11 | — | — | US | disclosed |
| US-20110319404-A1 | METHOD FOR TREATING NON-HODKIN'S LYMPHOMA | SYNTA PHARMACEUTICALS CORP. | 2011-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319404-A1 | METHOD FOR TREATING NON-HODKIN'S LYMPHOMA | HSP90AB1, HSP90AA1, HSP90B1 | GAA 157/4885MEN1 4111/4885KMT2A 2805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.