Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1149360 | 0.93 | MEN1 (0.38) | MEN1KMT2AMAPTPOLBGAA | |
| SCHEMBL1148187 | 0.82 | MEN1 (0.40) | MEN1KMT2AMAPTPOLBGAA | |
| SCHEMBL12046510 | 0.78 | GAA (0.37) | MEN1KMT2AMAPTPOLBGAA | |
| SCHEMBL14345498 | 0.76 | HSP90AA1 (0.38) | MEN1KMT2AMAPTPOLBGAA | |
| SCHEMBL14618520 | 0.75 | ATP4A (0.35) | MEN1KMT2AGAA | |
| SCHEMBL1148563 | 0.74 | HSP90AA1 (0.38) | MEN1KMT2AMAPTPOLBALDH1A1 | |
| SCHEMBL1343626 | 0.74 | GAA (0.39) | MEN1KMT2AMAPTPOLBGAA | |
| SCHEMBL14609912 | 0.74 | KMT2A (0.35) | MEN1KMT2AMAPTPOLBGAA | |
| SCHEMBL14609861 | 0.73 | KMT2A (0.38) | MEN1KMT2AMAPTPOLBGAA | |
| SCHEMBL14609858 | 0.73 | KMT2A (0.38) | MEN1KMT2AMAPTPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007021966-A1 | PYRAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2007-02-22 | — | — | WO | disclosed |