Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.43 |
| ▸ | PIK3R2 | O00459 | 6/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.43 |
| ▸ | PIK3R5 | Q8WYR1 | 6/20 | 0.43 |
| ▸ | PIK3R3 | Q92569 | 6/20 | 0.43 |
| ▸ | UGCG | Q16739 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12046638 | 0.94 | ALDH1A1 (0.40) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL1199419 | 0.90 | UGCG (0.41) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL1160202 | 0.86 | UGCG (0.40) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL12046639 | 0.85 | UGCG (0.38) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL12046621 | 0.83 | CCNA2 (0.51) | ALDH1A1HPGDTP53CCNA2CDK2 | |
| SCHEMBL12046624 | 0.79 | ALDH1A1 (0.58) | ALDH1A1HPGDMEN1KMT2ANPSR1 | |
| SCHEMBL12046637 | 0.78 | CCNA2 (0.46) | ALDH1A1HPGDTP53CCNA2CDK2 | |
| SCHEMBL1198440 | 0.78 | PDE7A (0.44) | ALDH1A1HPGDTP53CCNA2CDK2 | |
| SCHEMBL12046677 | 0.76 | UGCG (0.39) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2776761 | 0.75 | PDE10A (0.43) | MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459551-B1 | DIHYDROBENZOINDAZOLES | MERCK SHARP & DOHME (NL) | 2014-07-02 | — | — | EP | disclosed |
| US-8071589-B2 | Dihydrobenzoindazoles | N. V. ORGANON (NL) | 2011-12-06 | — | — | US | disclosed |
| US-8071589-B2 | Dihydrobenzoindazoles | N. V. ORGANON (NL) | 2011-12-06 | — | — | US | disclosed |
| WO-2011012674-A1 | DIHYDROBENZOINDAZOLES | N.V. ORGANON (NL) | 2011-02-03 | — | — | WO | disclosed |
| US-20110028451-A1 | Dihydrobenzoindazoles | N.V. ORGANON (NL) | 2011-02-03 | — | — | US | disclosed |
| US-20110028451-A1 | Dihydrobenzoindazoles | N.V. ORGANON (NL) | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028451-A1 | Dihydrobenzoindazoles | DHODH, BRDT, HSD17B11 | PIK3CD 2692/4885PIK3R2 2464/4885PIK3CA 3381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.