Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 10/20 | 1.00 |
| ▸ | CDK9 | P50750 | 7/20 | 1.00 |
| ▸ | CDK5 | Q00535 | 5/20 | 1.00 |
| ▸ | CDK1 | P06493 | 5/20 | 1.00 |
| ▸ | CDK12 | Q9NYV4 | 7/20 | 0.83 |
| ▸ | CCNK | O75909 | 6/20 | 0.83 |
| ▸ | CDK7 | P50613 | 5/20 | 0.83 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.83 |
| ▸ | GSK3B | P49841 | 3/20 | 0.83 |
| ▸ | CCNH | P51946 | 3/20 | 0.83 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.83 |
| ▸ | GSK3A | P49840 | 2/20 | 0.83 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.83 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.83 |
| ▸ | CDK13 | Q14004 | 2/20 | 0.83 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.83 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.83 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.83 |
| ▸ | BRD4 | O60885 | 1/20 | 0.83 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dinaciclib SCHEMBL30176832 | 0.91 | CDK2 (1.00) | CDK2CDK9CDK5CDK1CDK12 | |
| Dinaciclib SCHEMBL23682977 | 0.91 | CDK2 (1.00) | CDK2CDK9CDK5CDK1CDK12 | |
| Dinaciclib SCHEMBL15637863 | 0.91 | CDK2 (1.00) | CDK2CDK9CDK5CDK1CDK12 | |
| Dinaciclib SCHEMBL12048446 | 0.91 | CDK2 (1.00) | CDK2CDK9CDK5CDK1CDK12 | |
| SCHEMBL12954295 | 0.91 | CDK2 (0.83) | CDK2CDK9CDK5CDK1CDK12 | |
| SCHEMBL13116917 | 0.91 | CDK2 (0.83) | CDK2CDK9CDK5CDK1CDK12 | |
| SCHEMBL12953146 | 0.91 | CDK2 (0.83) | CDK2CDK9CDK5CDK1CDK12 | |
| SCHEMBL12953641 | 0.91 | CDK2 (0.83) | CDK2CDK9CDK5CDK1CDK12 | |
| SCHEMBL14276480 | 0.88 | CDK2 (0.79) | CDK2CDK9CDK5CDK1CDK12 | |
| SCHEMBL15576866 | 0.84 | CDK2 (0.73) | CDK2CDK9CDK5CDK1CDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076479-B2 | useful as cyclin-dependent kinase inhibitor compounds; minimizes the need for chromatographic purification of intermediates, and utilizes fewer changes of solvent systems | SCHERING CORPORATION (US) | 2011-12-13 | — | — | US | disclosed |
| US-20080058518-A1 | Process and intermediates for the synthesis of (3-alkyl-5-piperidin-1-yl-3,3a-dihydro-pyrazolo[1,5-a]pyrimidin-7-yl)-amino derivatives and intermediates | MERCK SHARP & DOHME LLC | 2008-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058518-A1 | Process and intermediates for the synthesis of (3-alkyl-5-piperidin-1-yl-3,3a-dihydro-pyrazolo[1,5-a]pyrimidin-7-yl)-amino derivatives and intermediates | CDK3, CDK7, CDK2 | CDK2 3/4885CDK9 6/4885CDK5 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.