Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dinaciclib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 known ✓ | P24941 | 12/20 | 1.00 |
| ▸ | CDK9 known ✓ | P50750 | 7/20 | 1.00 |
| ▸ | CDK5 known ✓ | Q00535 | 5/20 | 1.00 |
| ▸ | CDK1 known ✓ | P06493 | 5/20 | 1.00 |
| ▸ | CCNE1 | P24864 | 6/20 | 1.00 |
| ▸ | CDK12 | Q9NYV4 | 6/20 | 1.00 |
| ▸ | CCNK | O75909 | 5/20 | 1.00 |
| ▸ | CDK7 | P50613 | 4/20 | 1.00 |
| ▸ | GSK3B | P49841 | 3/20 | 1.00 |
| ▸ | GSK3A | P49840 | 2/20 | 1.00 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 1.00 |
| ▸ | CCNT1 | O60563 | 2/20 | 1.00 |
| ▸ | CCNH | P51946 | 2/20 | 1.00 |
| ▸ | MNAT1 | P51948 | 2/20 | 1.00 |
| ▸ | CDK13 | Q14004 | 2/20 | 1.00 |
| ▸ | CCNA2 | P20248 | 2/20 | 1.00 |
| ▸ | CCNA1 | P78396 | 2/20 | 1.00 |
| ▸ | CCNT2 | O60583 | 1/20 | 1.00 |
| ▸ | BRD4 | O60885 | 1/20 | 1.00 |
| ▸ | CCNB2 | O95067 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dinaciclib SCHEMBL12048446 | 1.00 | CDK2 (1.00) | CDK2CDK9CCNE1CDK12CDK5 | |
| Dinaciclib SCHEMBL23682977 | 1.00 | CDK2 (1.00) | CDK2CDK9CCNE1CDK12CDK5 | |
| Dinaciclib SCHEMBL30176832 | 1.00 | CDK2 (1.00) | CDK2CDK9CCNE1CDK12CDK5 | |
| SCHEMBL15576865 | 0.92 | CDK2 (0.86) | CDK2CDK9CCNE1CDK12CDK5 | |
| SCHEMBL20366942 | 0.92 | CDK2 (0.84) | CDK2CDK9CCNE1CDK12CDK5 | |
| SCHEMBL23815646 | 0.92 | CDK2 (0.84) | CDK2CDK9CCNE1CDK12CDK5 | |
| SCHEMBL16366036 | 0.91 | CDK2 (0.84) | CDK2CDK9CCNE1CDK12CDK5 | |
| SCHEMBL12048531 | 0.91 | CDK2 (1.00) | CDK2CDK9CCNE1CDK12CDK5 | |
| SCHEMBL18738298 | 0.90 | CDK2 (0.82) | CDK2CDK9CCNE1CDK12CDK5 | |
| SCHEMBL12953008 | 0.90 | CDK2 (0.81) | CDK2CDK9CCNE1CDK12CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160046672-A1 | STAPLING eIF4E INTERACTING PEPTIDES | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2016-02-18 | — | — | US | claimed |
| EP-2976354-A1 | STAPLING eIF4E INTERACTING PEPTIDES | Agency For Science, Technology And Research (SG) | 2016-01-27 | — | — | EP | claimed |
| US-20150246946-A1 | PEPTIDES AND METHODS FOR TREATING CANCER | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2015-09-03 | — | — | US | claimed |
| EP-2904000-A1 | PEPTIDES AND METHODS FOR TREATING CANCER | Agency for Science, Technology and Research (SG) | 2015-08-12 | — | — | EP | claimed |
| WO-2014149001-A1 | STAPLING eIF4E INTERACTING PEPTIDES | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2014-09-25 | — | — | WO | claimed |
| WO-2014055039-A1 | PEPTIDES AND METHODS FOR TREATING CANCER | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2014-04-10 | — | — | WO | claimed |
| US-11319344-B2 | Non-membrane disruptive P53 activating stapled peptides | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2022-05-03 | — | — | US | disclosed |
| EP-3256484-B1 | NON-MEMBRANE DISRUPTIVE P53 ACTIVATING STAPLED PEPTIDES | AGENCY SCIENCE TECH & RES (SG) | 2021-06-23 | — | — | EP | disclosed |
| US-20180030090-A1 | NON-MEMBRANE DISRUPTIVE P53 ACTIVATING STAPLED PEPTIDES | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2018-02-01 | — | — | US | disclosed |
| EP-3256484-A1 | NON-MEMBRANE DISRUPTIVE p53 ACTIVATING STAPLED PEPTIDES | Agency For Science, Technology And Research (SG) | 2017-12-20 | — | — | EP | disclosed |
| WO-2016130092-A1 | NON-MEMBRANE DISRUPTIVE P53 ACTIVATING STAPLED PEPTIDES | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2016-08-18 | — | — | WO | disclosed |
| US-20160046672-A1 | STAPLING eIF4E INTERACTING PEPTIDES | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2016-02-18 | — | — | US | disclosed |
| EP-2976354-A1 | STAPLING eIF4E INTERACTING PEPTIDES | Agency For Science, Technology And Research (SG) | 2016-01-27 | — | — | EP | disclosed |
| WO-2015192123-A1 | FAP-ACTIVATED THERAPEUTIC AGENTS, AND USES RELATED THERETO | TRUSTEES OF TUFTS COLLEGE (US) | 2015-12-17 | — | — | WO | disclosed |
| US-20150246946-A1 | PEPTIDES AND METHODS FOR TREATING CANCER | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2015-09-03 | — | — | US | disclosed |
| EP-2904000-A1 | PEPTIDES AND METHODS FOR TREATING CANCER | Agency for Science, Technology and Research (SG) | 2015-08-12 | — | — | EP | disclosed |
| WO-2014149001-A1 | STAPLING eIF4E INTERACTING PEPTIDES | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014055039-A1 | PEPTIDES AND METHODS FOR TREATING CANCER | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2014-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11319344-B2 | Non-membrane disruptive P53 activating stapled peptides | TP53, ANXA3, ANXA2 | CDK2 3712/4885CDK9 4446/4885CDK5 4042/4885 |
| US-20180030090-A1 | NON-MEMBRANE DISRUPTIVE P53 ACTIVATING STAPLED PEPTIDES | TP53, ANXA3, ANXA2 | CDK2 3521/4885CDK9 4390/4885CDK5 3945/4885 |
| US-20160046672-A1 | STAPLING eIF4E INTERACTING PEPTIDES | EIF4EBP1, EIF4E, EIF4G2 | CDK2 2158/4885CDK9 2458/4885CDK5 1427/4885 |
| US-20150246946-A1 | PEPTIDES AND METHODS FOR TREATING CANCER | TP53, MDM4, MDM2 | CDK2 207/4885CDK9 595/4885CDK5 749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.