Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12049213 | 0.94 | KDR (0.54) | KDRPDGFRBPDGFRAAURKACDK1 | |
| SCHEMBL12049412 | 0.91 | PDGFRB (0.45) | KDRPDGFRBPDGFRAAURKACDK1 | |
| SCHEMBL12049330 | 0.89 | PDGFRB (0.44) | KDRPDGFRBPDGFRACSF1RMAPK7 | |
| SCHEMBL12049143 | 0.88 | KDR (0.53) | KDRPDGFRBPDGFRAAURKACDK1 | |
| SCHEMBL12049878 | 0.88 | IDO1 (0.43) | KDRPDGFRBPDGFRAAURKACDK1 | |
| SCHEMBL12049335 | 0.87 | NAMPT (0.47) | PDGFRBPDGFRACSF1RMAPT | |
| SCHEMBL12049308 | 0.87 | PDGFRB (0.46) | KDRPDGFRBPDGFRACSF1RMAPK7 | |
| SCHEMBL12049343 | 0.87 | CSF1R (0.44) | PDGFRBPDGFRACSF1RMAPK7 | |
| SCHEMBL12049344 | 0.86 | PDGFRB (0.48) | PDGFRBPDGFRAAURKACSF1RMAPK7 | |
| SCHEMBL12049313 | 0.86 | NAMPT (0.47) | PDGFRBPDGFRACSF1RMAPK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071768-B2 | Alkylquinoline and alkylquinazoline kinase modulators | JANSSEN PHARMACEUTICA, N.V. (BE) | 2011-12-06 | — | — | US | disclosed |
| US-8071768-B2 | Alkylquinoline and alkylquinazoline kinase modulators | JANSSEN PHARMACEUTICA, N.V. (BE) | 2011-12-06 | — | — | US | disclosed |
| US-20070004660-A1 | Synergistic Modulation of Flt3 Kinase Using Alkylquinolines and Alkylquinazolines | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-01-04 | — | — | US | disclosed |
| US-20070004660-A1 | Synergistic Modulation of Flt3 Kinase Using Alkylquinolines and Alkylquinazolines | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004660-A1 | Synergistic Modulation of Flt3 Kinase Using Alkylquinolines and Alkylquinazolines | FLT3, MCL1, CDC42BPG | KDR 257/4885PDGFRB 224/4885PDGFRA 262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.