SCHEMBL120551

SCHEMBL120551

Nc1ncnc2c1ncn2[C@@H]1O[C@H](COC2CCCC2)[C@@H](O)[C@H]1O

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 4/20 0.69
ADORA1 P30542 3/20 0.67
SMN1; SMN2 Q16637 3/20 0.67
ADORA2A P29274 2/20 0.67
ADORA2B P29275 2/20 0.67
DPP4 P27487 1/20 0.67
MEN1 O00255 1/20 0.67
SLC28A1 O00337 1/20 0.67
MAP3K7 O43318 1/20 0.67
SLC28A2 O43868 1/20 0.67
GAPDH P04406 1/20 0.67
MAPK1 P28482 1/20 0.67
STAT6 P42226 1/20 0.67
PI4KA P42356 1/20 0.67
KMT2A Q03164 1/20 0.67
PI4K2B Q8TCG2 1/20 0.67
DOT1L Q8TEK3 1/20 0.67
SLC29A1 Q99808 1/20 0.67
PI4K2A Q9BTU6 1/20 0.67
SLC28A3 Q9HAS3 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL120562 0.99 ADORA3 (0.68) ADORA3ADORA1SMN1; SMN2ADORA2AADORA2B
SCHEMBL10689183 0.96 ADORA3 (0.73) ADORA3ADORA1SMN1; SMN2ADORA2AADORA2B
SCHEMBL8608782 0.93 ADORA3 (0.69) ADORA3ADORA1SMN1; SMN2ADORA2AADORA2B
SCHEMBL8609365 0.93 ADORA3 (0.69) ADORA3ADORA1SMN1; SMN2ADORA2AADORA2B
SCHEMBL8608418 0.91 ADORA1 (0.61) ADORA3ADORA1SMN1; SMN2ADORA2AADORA2B
SCHEMBL5063589 0.90 ADORA1 (0.65) ADORA3ADORA1SMN1; SMN2ADORA2AADORA2B
SCHEMBL7909170 0.89 MEN1 (0.57) ADORA3ADORA1SMN1; SMN2MEN1KMT2A
SCHEMBL8606939 0.89 ADORA1 (0.64) ADORA3ADORA1SMN1; SMN2ADORA2AADORA2B
SCHEMBL8606410 0.89 ADORA1 (0.64) ADORA3ADORA1SMN1; SMN2ADORA2AADORA2B
SCHEMBL3699111 0.88 MEN1 (0.59) ADORA3ADORA1SMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 845 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240024243-A1 Fine Dry Particulate Adenosine Compositions and Topical Formulations Including the Same LABORATORY SKIN CARE, INC. 2024-01-25 US claimed
US-20190125779-A1 PHARMACEUTICAL COMPOSITIONS UNIVERSITY OF HOUSTON SYSTEM (US) 2019-05-02 US claimed
WO-2018091689-A1 SKELETAL MUSCLE HYPERTROPHY INDUCERS CYTOO (FR) 2018-05-24 WO claimed
EP-3247715-A1 METHODS OF PREVENTING, REDUCING OR TREATING MACULAR DEGENERATION Inotek Pharmaceuticals Corporation (US) 2017-11-29 EP claimed
WO-2017137528-A1 ADENOSINE A1 RECEPTOR AGONIST FOR USE IN TREATMENT OF STATUS EPILEPTICUS CHARITÉ - UNIVERSITÄTSMEDIZIN BERLIN (DE) 2017-08-17 WO claimed
US-20160367586-A1 COMBINATION, KIT AND METHOD OF REDUCING INTRAOCULAR PRESSURE INOTEK PHARMACEUTICALS CORPORATION 2016-12-22 US claimed
WO-2016109624-A1 PHARMACEUTICAL COMPOSITIONS UNIVERSITY OF HOUSTON SYSTEM (US) 2016-07-07 WO claimed
US-20160158268-A1 METHOD OF REDUCING INTRAOCULAR PRESSURE IN HUMANS INOTEK PHARMACEUTICALS CORPORATION 2016-06-09 US claimed
US-20160158267-A1 METHODS OF PREVENTING, REDUCING OR TREATING MACULAR DEGENERATION INOTEK PHARMACEUTICALS CORPORATION 2016-06-09 US claimed
WO-2016090005-A1 METHODS OF PREVENTING, REDUCING OR TREATING MACULAR DEGENERATION INOTEK PHARMACEUTICALS CORPORATION (US) 2016-06-09 WO claimed
WO-1998019674-A2 A METHOD FOR TREATING TENSION-TYPE HEADACHE HEAD EXPLORER APS (DK) 1998-05-14 WO claimed
WO-1998015276-A1 COMPOSITIONS AND METHODS FOR MODULATING MELANIN PRODUCTION THERASYS, INC. (US) 1998-04-16 WO claimed
EP-0735888-A1 PURINE COMPOSITIONS AND METHODS FOR ADMINISTRATION FUKUNAGA, Atsuo F. (US) 1996-10-09 EP claimed
WO-1995014478-A1 PURINE COMPOSITIONS AND METHODS FOR ADMINISTRATION FUKUNAGA ATSUO F (US) 1995-06-01 WO claimed
EP-0589964-A4 METHOD AND COMPOSITION TO REDUCE MYOCARDIAL REPERFUSION INJURY UNIV VANDERBILT (US) 1994-05-25 EP claimed
EP-0589964-A1 METHOD AND COMPOSITION TO REDUCE MYOCARDIAL REPERFUSION INJURY VANDERBILT UNIVERSITY (US) 1994-04-06 EP claimed
WO-1992020346-A1 METHOD AND COMPOSITION TO REDUCE MYOCARDIAL REPERFUSION INJURY VANDERBILT UNIVERSITY (US) 1992-11-26 WO claimed
US-5070877-A Using adenosin receptor agonist MEDCO RESEARCH, INC. (US) 1991-12-10 US claimed
EP-0181129-B1 N6-SUBSTITUTED DEOXYRIBOSE ANALOGS OF ADENOSINES WARNER-LAMBERT COMPANY (US) 1989-03-08 EP claimed
EP-0181129-A2 N6-substituted deoxyribose analogs of adenosines WARNER-LAMBERT COMPANY (US) 1986-05-14 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160158267-A1 METHODS OF PREVENTING, REDUCING OR TREATING MACULAR DEGENERATION ADORA2A, ADORA1, PDE6C ADORA3 4/4885ADORA1 2/4885SMN1; SMN2 1976/4885
US-20160367586-A1 COMBINATION, KIT AND METHOD OF REDUCING INTRAOCULAR PRESSURE PTGIR, ADORA1, PDE3A ADORA3 7/4885ADORA1 2/4885SMN1; SMN2 4752/4885
US-20160158268-A1 METHOD OF REDUCING INTRAOCULAR PRESSURE IN HUMANS PDE3A, PDE2A, PDE6C ADORA3 31/4885ADORA1 18/4885SMN1; SMN2 4793/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.