Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.50 |
| ▸ | IRAK4 | Q9NWZ3 | 15/20 | 0.46 |
| ▸ | ILK | Q13418 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12057857 | 0.88 | DYRK1A (0.51) | DYRK1AIRAK4ILK | |
| SCHEMBL12057841 | 0.87 | IRAK4 (0.44) | DYRK1AIRAK4 | |
| SCHEMBL12058464 | 0.87 | IRAK4 (0.58) | IRAK4 | |
| SCHEMBL13493457 | 0.87 | IRAK4 (0.50) | DYRK1AIRAK4 | |
| SCHEMBL12057788 | 0.86 | DYRK1A (0.49) | DYRK1AIRAK4ILK | |
| SCHEMBL12058448 | 0.85 | IRAK4 (0.46) | DYRK1AIRAK4 | |
| SCHEMBL12057800 | 0.84 | IRAK4 (0.65) | IRAK4 | |
| SCHEMBL12058251 | 0.83 | IRAK4 (0.40) | IRAK4 | |
| SCHEMBL12058008 | 0.81 | IRAK4 (0.57) | IRAK4 | |
| SCHEMBL12058209 | 0.81 | IRAK4 (0.57) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110318305-A1 | SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS | MERCK SHARP & DOHME LLC | 2011-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110318305-A1 | SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS | PNP, XDH, PNPO | DYRK1A 463/4885IRAK4 706/4885ILK 4638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.