Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 10/20 | 0.62 |
| ▸ | CCND1 | P24385 | 8/20 | 0.62 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.60 |
| ▸ | CDK2 | P24941 | 3/20 | 0.59 |
| ▸ | CDK1 | P06493 | 3/20 | 0.59 |
| ▸ | EGFR | P00533 | 3/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.56 |
| ▸ | CCND3 | P30281 | 5/20 | 0.55 |
| ▸ | CCND2 | P30279 | 4/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 2/20 | 0.55 |
| ▸ | CCNK | O75909 | 1/20 | 0.55 |
| ▸ | CDK9 | P50750 | 1/20 | 0.55 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.55 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.55 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30620425 | 0.88 | CDK4 (0.67) | CDK4CCND1ALKCDK2CDK1 | |
| SCHEMBL270386 | 0.88 | CDK4 (0.67) | CDK4CCND1ALKCDK2CDK1 | |
| SCHEMBL12065029 | 0.86 | ALK (0.63) | ALKCDK2EGFRFLT3CCND3 | |
| SCHEMBL14001919 | 0.84 | ALK (0.77) | ALKCDK2EGFRMAP4K1CCND3 | |
| SCHEMBL12197982 | 0.84 | CDK4 (0.57) | CDK4CCND1ALKCDK2CDK1 | |
| SCHEMBL2479934 | 0.84 | NPC1 (0.60) | CDK4CCND1ALKCDK2CDK1 | |
| SCHEMBL2951233 | 0.83 | ALK (0.62) | CDK4CCND1ALKCDK2EGFR | |
| SCHEMBL12064885 | 0.83 | ALK (0.59) | CDK4CCND1ALKCDK2CDK1 | |
| SCHEMBL14837275 | 0.82 | SYK (0.73) | ALKEGFRSYKBRD4 | |
| SCHEMBL14847406 | 0.82 | EGFR (0.62) | CDK4CCND1ALKCDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2578584-B1 | ARYLAMINO PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | SI CHUAN UNIV (CN) | 2020-08-12 | — | — | EP | disclosed |
| EP-2578584-B1 | ARYLAMINO PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | SI CHUAN UNIV (CN) | 2020-08-12 | — | — | EP | disclosed |
| CN-105832740-B | Aryl amine purine derivative and preparation method thereof and purposes in medicine | 石药集团中奇制药技术（石家庄）有限公司 | 2019-02-12 | — | — | CN | disclosed |
| CN-105832740-A | Aromatic amino purine derivative as well as preparation method and pharmaceutical application thereof | 石药集团中奇制药技术（石家庄）有限公司 | 2016-08-10 | — | — | CN | disclosed |
| CN-103003278-B | Arylamino purine derivatives, preparation method and medical application thereof | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) Co.,Ltd. (CN) | 2016-03-30 | — | — | CN | disclosed |
| US-9096601-B2 | Arylamino purine derivatives, preparation method and pharmaceutical use thereof | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD. (CN) | 2015-08-04 | — | — | US | disclosed |
| US-9096601-B2 | Arylamino purine derivatives, preparation method and pharmaceutical use thereof | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD. (CN) | 2015-08-04 | — | — | US | disclosed |
| US-9096601-B2 | Arylamino purine derivatives, preparation method and pharmaceutical use thereof | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD. (CN) | 2015-08-04 | — | — | US | disclosed |
| US-20130203986-A1 | Arylamino Purine Derivatives, Preparation Method and Pharmaceutical Use Thereof | SI Chuaan University (CN) | 2013-08-08 | — | — | US | disclosed |
| US-20130203986-A1 | Arylamino Purine Derivatives, Preparation Method and Pharmaceutical Use Thereof | SI Chuaan University (CN) | 2013-08-08 | — | — | US | disclosed |
| US-20130203986-A1 | Arylamino Purine Derivatives, Preparation Method and Pharmaceutical Use Thereof | SI Chuaan University (CN) | 2013-08-08 | — | — | US | disclosed |
| EP-2578584-A1 | ARYLAMINO PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | Si Chuan University (CN) | 2013-04-10 | — | — | EP | disclosed |
| EP-2578584-A1 | ARYLAMINO PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | Si Chuan University (CN) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011147066-A1 | ARYLAMINO PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 四川大学 (CN) | 2011-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130203986-A1 | Arylamino Purine Derivatives, Preparation Method and Pharmaceutical Use Thereof | EGFR, PNP, GART | CDK4 1380/4885CCND1 905/4885ALK 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.