Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.60 |
| ▸ | CDK4 | P11802 | 8/20 | 0.57 |
| ▸ | CCND1 | P24385 | 7/20 | 0.57 |
| ▸ | CDK2 | P24941 | 4/20 | 0.56 |
| ▸ | CDK1 | P06493 | 3/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.56 |
| ▸ | FLT3 | P36888 | 2/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.56 |
| ▸ | CDK9 | P50750 | 2/20 | 0.56 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.56 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.56 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29310350 | 0.86 | SLC2A1 (0.60) | SLC2A1CDK4CCND1CDK2CDK1 | |
| SCHEMBL29310349 | 0.86 | ALK (0.60) | SLC2A1CDK4CCND1CDK2CDK1 | |
| SCHEMBL2482380 | 0.85 | SLC2A1 (0.65) | SLC2A1CDK4CCND1CDK2CDK1 | |
| SCHEMBL29311092 | 0.84 | SLC2A1 (0.56) | SLC2A1CDK4CCND1CDK2CDK1 | |
| SCHEMBL12064950 | 0.84 | CDK4 (0.62) | CDK4CCND1CDK2CDK1CCNA2 | |
| SCHEMBL2483649 | 0.84 | SLC2A1 (0.63) | NPC1RAB9ASLC2A1CDK4CCND1 | |
| SCHEMBL30620425 | 0.83 | CDK4 (0.67) | CDK4CCND1CDK2CDK1CCNA2 | |
| SCHEMBL270386 | 0.83 | CDK4 (0.67) | CDK4CCND1CDK2CDK1CCNA2 | |
| SCHEMBL16120478 | 0.82 | CDK4 (0.53) | SLC2A1CDK4CCND1CDK2CDK1 | |
| SCHEMBL17709572 | 0.82 | CDK4 (0.53) | SLC2A1CDK4CCND1CDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10730860-B2 | Diaminopyrimidine benzenesulfone derivatives and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-08-04 | — | — | US | disclosed |
| US-20190135790-A1 | DIAMINOPYRIMIDINE BENZENESULFONE DERIVATIVES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-05-09 | — | — | US | disclosed |
| US-10150756-B2 | Diaminopyrimidine benzenesulfone derivatives and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-12-11 | — | — | US | disclosed |
| EP-3099677-A1 | DIAMINOPYRIMIDINE BENZENESULFONE DERIVATIVES AND USES THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2016-12-07 | — | — | EP | disclosed |
| US-20160332993-A1 | DIAMINOPYRIMIDINE BENZENESULFONE DERIVATIVES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-11-17 | — | — | US | disclosed |
| CN-106029653-A | Diaminopyrimidine benzenesulfone derivatives and uses thereof | 达纳-法伯癌症研究所股份有限公司 | 2016-10-12 | — | — | CN | disclosed |
| EP-2376493-B1 | DIHYDROPYRIMIDOPYRIMIDINE DERIVATIVE | MSD KK (JP) | 2016-10-05 | — | — | EP | disclosed |
| EP-2376493-B1 | DIHYDROPYRIMIDOPYRIMIDINE DERIVATIVE | MSD KK (JP) | 2016-10-05 | — | — | EP | disclosed |
| WO-2015117053-A1 | DIAMINOPYRIMIDINE BENZENESULFONE DERIVATIVES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-08-06 | — | — | WO | disclosed |
| US-8507505-B2 | Dihydropyrazolopyrimidinone derivative | MSD K.K. (JP) | 2013-08-13 | — | — | US | disclosed |
| US-8507505-B2 | Dihydropyrazolopyrimidinone derivative | MSD K.K. (JP) | 2013-08-13 | — | — | US | disclosed |
| EP-2376493-A1 | DIHYDROPYRIMIDOPYRIMIDINE DERIVATIVE | MSD K.K. (JP) | 2011-10-19 | — | — | EP | disclosed |
| US-20110243891-A1 | DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVE | MSD K.K. | 2011-10-06 | — | — | US | disclosed |
| US-20110243891-A1 | DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVE | MSD K.K. | 2011-10-06 | — | — | US | disclosed |
| WO-2010067886-A1 | DIHYDROPYRIMIDOPYRIMIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-06-17 | — | — | WO | disclosed |
| WO-2010067886-A1 | DIHYDROPYRIMIDOPYRIMIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160332993-A1 | DIAMINOPYRIMIDINE BENZENESULFONE DERIVATIVES AND USES THEREOF | BRDT, BRD4, BRPF3 | NPC1 4679/4885RAB9A 4076/4885SLC2A1 4715/4885 |
| US-10150756-B2 | Diaminopyrimidine benzenesulfone derivatives and uses thereof | BRDT, BRD4, BRPF3 | NPC1 4679/4885RAB9A 4076/4885SLC2A1 4715/4885 |
| US-20190135790-A1 | DIAMINOPYRIMIDINE BENZENESULFONE DERIVATIVES AND USES THEREOF | BRDT, BRD4, BRPF3 | NPC1 4679/4885RAB9A 4076/4885SLC2A1 4715/4885 |
| US-10730860-B2 | Diaminopyrimidine benzenesulfone derivatives and uses thereof | BRDT, BRD4, BRPF3 | NPC1 4679/4885RAB9A 4076/4885SLC2A1 4715/4885 |
| US-20110243891-A1 | DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVE | WEE2, WEE1, RPS6KA1 | NPC1 3849/4885RAB9A 1570/4885SLC2A1 2999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.