Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.52 |
| ▸ | CDK8 | P49336 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 5/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.45 |
| ▸ | CDK9 | P50750 | 7/20 | 0.45 |
| ▸ | CSF1R | P07333 | 3/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12056894 | 0.93 | CCNC (0.50) | CCNCCDK8FYNCCNT1CDK9 | |
| SCHEMBL12064822 | 0.88 | FYN (0.52) | CCNCCDK8FYNCCNT1CDK9 | |
| SCHEMBL12064805 | 0.86 | CCNC (0.53) | CCNCCDK8FYNCCNT1CDK9 | |
| SCHEMBL12064718 | 0.85 | CCNT1 (0.54) | CCNCCDK8FYNCCNT1CDK9 | |
| SCHEMBL5203867 | 0.84 | CCNC (0.60) | CCNCCDK8FYNCCNT1CDK9 | |
| SCHEMBL12698727 | 0.84 | CCNC (0.60) | CCNCCDK8FYNCCNT1CDK9 | |
| SCHEMBL12065316 | 0.83 | FYN (0.57) | CCNCCDK8FYNCCNT1CDK9 | |
| SCHEMBL12064807 | 0.82 | CCNT1 (0.54) | CCNCCDK8FYNCCNT1CDK9 | |
| SCHEMBL12065011 | 0.81 | CCNC (0.48) | CCNCCDK8FYNCCNT1CDK9 | |
| SCHEMBL12065366 | 0.81 | CSF1R (0.51) | CCNCCDK8FYNCCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8084456-B2 | Pyrazine-based tubulin inhibitors | YM BIOSCIENCES AUSTRALIA PTY LTD (AU) | 2011-12-27 | — | — | US | disclosed |
| US-20070082894-A1 | Pyrazine-based tubulin inhibitors | CYTOPIA PTY LTD (AU) | 2007-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082894-A1 | Pyrazine-based tubulin inhibitors | TUBB1, TUBA1C, TUBB | CCNC 540/4885CDK8 429/4885FYN 2703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.