TUBB

Tubulin beta-5 chain · P07437 · TUBB on Sugi Atlas →

135,161 patent compounds predicted against TUBB, 85,913 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Curacin A Curacin A (SCHEMBL61304) 1.00 20/20
Vintriptol Vintriptol (SCHEMBL93959) 1.00 15/20
Vindesine Vindesine (SCHEMBL4420) 0.85 13/20
Vindesine Vindesine (SCHEMBL4421) 0.85 13/20
Vindesine Vindesine (SCHEMBL4285) 0.85 12/20
SCHEMBL147173 SCHEMBL147173 0.50 12/20
SCHEMBL147174 SCHEMBL147174 0.50 12/20
Combretastatin Combretastatin (SCHEMBL19955) 1.00 9/20
Combretastatin Combretastatin (SCHEMBL19956) 1.00 9/20
SCHEMBL118593 SCHEMBL118593 0.69 9/20
Centaureidin Centaureidin (SCHEMBL9953) 1.00 8/20
Thiocolchicine Thiocolchicine (SCHEMBL43160) 1.00 8/20
Thiocolchicine Thiocolchicine (SCHEMBL43161) 1.00 8/20
SCHEMBL68067 SCHEMBL68067 0.62 8/20
Fosbretabulin Fosbretabulin (SCHEMBL66079) 0.61 8/20
Vinorelbine Vinorelbine (SCHEMBL4765) 1.00 7/20
Combretastatin A4 Combretastatin A4 (SCHEMBL18945) 1.00 7/20
Combretastatin A4 Combretastatin A4 (SCHEMBL18946) 1.00 7/20
Levofloxacin Anhydrous Levofloxacin Anhydrous (SCHEMBL15397) 0.98 7/20
Ofloxacin Ofloxacin (SCHEMBL24373) 0.98 7/20

Clinical trials — most relevant to TUBB by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Comparative Analysis of the Efficacies in Neoadjuvant Chemotherapy of Breast Cancer PHASE3COMPLETED
Eribulin Mesylate or Paclitaxel as First- or Second-Line Therapy in Treating Patients With Recurrent Stage IIIC-IV Breast Cancer PHASE3SUSPENDED
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU) PHASE2/PHASE3ACTIVE_NOT_RECRUITING
The ECLA PHRI COLCOVID Trial. Effects of Colchicine on Moderate/High-risk Hospitalized COVID-19 Patients. PHASE3COMPLETED
IVM Alone vs ALB + IVM Against Onchocerciasis PHASE3COMPLETED
Vit D and Peripheral Neuropathy in Taxane Naive Patients PHASE2UNKNOWN
A Multicenter Study of NAP (AL-108) in Schizophrenia PHASE2COMPLETED
First-line Gemcitabine Plus Cisplatin in Locally Advanced (IIIC Stage) Breast Cancer Patients PHASE2ACTIVE_NOT_RECRUITING
SB-715992 in Treating Patients With Locally Advanced, Recurrent, or Metastatic Liver Cancer PHASE2COMPLETED
Vinorelbine in Relapsed Platinum Resistant or Refractory C5 High Grade Serous, Endometrioid, or Undifferentiated Primary Peritoneum, Fallopian Tube or Ovarian Cancer PHASE2UNKNOWN
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Esophageal Cancer PHASE2COMPLETED
Biologic Correlative Taxotere/AC PHASE2COMPLETED
Neoadjuvant Paclitaxel Plus Epirubicin Versus Vinorelbine Plus Epirubicin in Breast Cancer With TEKT4 Variations PHASE2COMPLETED
Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer PHASE1/PHASE2NOT_YET_RECRUITING
Therapy With Docetaxel and ZD1839 for Patients Who Have Advanced Breast Cancer PHASE2COMPLETED
Study of ABT-751 in Patients With Refractory Hematologic Malignancies PHASE1COMPLETED
Treating Patients With Advanced Solid Tumors, Breast Cancer or Recurrent Ovarian Cancer PHASE1COMPLETED
SB-715992 in Treating Patients With Acute Leukemia, Chronic Myelogenous Leukemia, or Advanced Myelodysplastic Syndromes PHASE1COMPLETED
Phase I Study of Oral BAY 1217389 in Combination With Intravenous Paclitaxel PHASE1COMPLETED
Exploratory Evaluation of [11C]MPC6827 EARLY_PHASE1COMPLETED
Diagnostic of Chemotherapy Induced Neuropathy in Children nanCOMPLETED
Generating Intervals of Reference FFor Early Life Brain Biomarkers. nanRECRUITING
Prostate Cancer Antigen 3 (PCA-3) Gene Project nanCOMPLETED
Effect of Low Dose of Colchicine on Platelet Reactivity nanCOMPLETED
CRF vs WCRF or PRF-DRG in CLBP of FJ Origin and RFA Failure of MBDR: Central Sensitization and Aberrant Nerve Sprouting nanUNKNOWN
Importance of the Microtubule Cytoskeleton in Oocyte Competence nanCOMPLETED
KCNA3 and OTOP2 Gene Methylation Combined Detection Kit (Fluorescent PCR Method) nanCOMPLETED
Evaluation of a Novel PET Radioligand to Image OGA nanCOMPLETED
Autophagy Bladder Cancer nanUNKNOWN
Correlation Between Autophagy-related Proteins and Inflammatory Markers in Hemodialysis Patients nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a TUBB binder may also engage these)

ProteinNameSimilarity
P69893 1.000 P69893 →
P68372 1.000 P68372 →
Q3MHM5 1.000 Q3MHM5 →
P11833 1.000 P11833 →
Q6GLE7 1.000 Q6GLE7 →
Q5R943 1.000 Q5R943 →
TUBB2B Tubulin beta-2B chain 1.000 landscape →
TUBB2A Tubulin beta-2A chain 1.000 landscape →
P85108 1.000 P85108 →
Q4R4X8 1.000 Q4R4X8 →
Q6B856 1.000 Q6B856 →
P46265 1.000 P46265 →
O44388 1.000 O44388 →
P69895 1.000 P69895 →
Q7JJU6 1.000 Q7JJU6 →
P99024 1.000 P99024 →
P09244 1.000 P09244 →
Q2KJD0 1.000 Q2KJD0 →
Q767L7 1.000 Q767L7 →
P69897 1.000 P69897 →
Q27U48 1.000 Q27U48 →
Q91575 1.000 Q91575 →
Q2HJ81 1.000 Q2HJ81 →
Q6P9T8 1.000 Q6P9T8 →
P12456 1.000 P12456 →
P30883 1.000 P30883 →
O59837 1.000 O59837 →
Q91240 1.000 Q91240 →
TUBB4A Tubulin beta-4A chain 1.000 landscape →
Q9YHC3 1.000 Q9YHC3 →