Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 3/20 | 0.86 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.86 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.86 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.86 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.86 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.86 |
| ▸ | TSPO | P30536 | 1/20 | 0.86 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.86 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.86 |
| ▸ | PLA2G4A | P47712 | 3/20 | 0.60 |
| ▸ | SGPL1 | O95470 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.53 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.53 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.53 |
| ▸ | LPAR4 | Q99677 | 2/20 | 0.53 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.53 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12766764 | 0.93 | S1PR1 (1.00) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 | |
| SCHEMBL3885 | 0.93 | S1PR1 (1.00) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 | |
| SCHEMBL6055753 | 0.93 | S1PR1 (1.00) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 | |
| SCHEMBL8736952 | 0.93 | S1PR1 (1.00) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 | |
| SCHEMBL3517452 | 0.93 | S1PR1 (1.00) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 | |
| SCHEMBL2561998 | 0.93 | S1PR1 (1.00) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 | |
| SCHEMBL17482409 | 0.93 | S1PR1 (1.00) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 | |
| SCHEMBL22910837 | 0.93 | S1PR1 (1.00) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 | |
| SCHEMBL20798182 | 0.93 | S1PR1 (1.00) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 | |
| SCHEMBL29438139 | 0.93 | S1PR1 (1.00) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7888527-B2 | Aryl amide sphingosine 1-phosphate analogs | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-02-15 | — | — | US | disclosed |
| US-7888527-B2 | Aryl amide sphingosine 1-phosphate analogs | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-02-15 | — | — | US | disclosed |
| US-20090137531-A1 | Aryl Amide Sphingosine 1- | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2009-05-28 | — | — | US | disclosed |
| EP-1827606-A2 | ARYL AMIDE SPHINGOSINE 1-PHOSPHATE ANALOGS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2007-09-05 | — | — | EP | disclosed |
| EP-1827606-A2 | ARYL AMIDE SPHINGOSINE 1-PHOSPHATE ANALOGS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006063033-A3 | ARYL AMIDE SPHINGOSINE 1-PHOSPHATE ANALOGS | UNIV VIRGINIA (US) | 2006-11-09 | — | — | WO | disclosed |
| WO-2006063033-A2 | ARYL AMIDE SPHINGOSINE 1-PHOSPHATE ANALOGS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2006-06-15 | — | — | WO | disclosed |
| WO-2006063033-A2 | ARYL AMIDE SPHINGOSINE 1-PHOSPHATE ANALOGS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2006-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137531-A1 | Aryl Amide Sphingosine 1- | S1PR3, S1PR1, S1PR4 | S1PR1 2/4885S1PR4 3/4885S1PR3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.