⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5108998 | 0.60 | — | — | |
| SCHEMBL5899081 | 0.56 | — | — | |
| SCHEMBL1351735 | 0.48 | — | — | |
| SCHEMBL21351776 | 0.48 | ADRA2A (0.36) | — | |
| SCHEMBL3117258 | 0.48 | — | — | |
| SCHEMBL4645948 | 0.46 | — | — | |
| SCHEMBL245729 | 0.44 | — | — | |
| SCHEMBL31520440 | 0.42 | UHRF1 (0.41) | — | |
| SCHEMBL7703054 | 0.40 | — | — | |
| SCHEMBL8758 | 0.40 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1058679-B1 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO AND ANALOGUES THEROF | SLOAN KETTERING INST CANCER (US) | 2005-10-19 | — | — | EP | claimed |
| US-20050043376-A1 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-02-24 | — | — | US | claimed |
| US-20050033059-A1 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-02-10 | — | — | US | claimed |
| US-20040260098-A1 | Synthesis of epothilones, intermediates thereto and analogues thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-12-23 | — | — | US | claimed |
| US-20040044221-A1 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-03-04 | — | — | US | claimed |
| EP-1386922-A2 | Synthesis of epothilones, intermediates thereof, analogues and uses thereof | Sloan-Kettering Institute For Cancer Research (US) | 2004-02-04 | — | — | EP | claimed |
| US-20040019089-A1 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof | SLOAN-KETTERING INST CAN RESEARCH | 2004-01-29 | — | — | US | claimed |
| US-20030208080-A1 | Synthesis of epothilones, intermediates thereto and analogues thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-11-06 | — | — | US | claimed |
| US-20030171596-A1 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-09-11 | — | — | US | claimed |
| US-6603023-B2 | Synthetic methods for preparing intermediates for the preparation of epothilones A and B, and desoxyepothilones A and B, and related compounds useful as anticancer therapeutics | SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH | 2003-08-05 | — | — | US | claimed |
| EP-1058679-A4 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO AND ANALOGUES THEROF | SLOAN KETTERING INST CANCER (US) | 2002-08-07 | — | — | EP | claimed |
| US-20020002194-A1 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-01-03 | — | — | US | claimed |
| US-6316630-B1 | TREATING EPOTHILONE TO DEOXYGENATE THE EPOTHILONE, AND THEREBY TO PROVIDE THE DESOXYEPOTHILONE | SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH | 2001-11-13 | — | — | US | claimed |
| EP-0977563-A4 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF | SLOAN KETTERING INST CANCER (US) | 2001-04-25 | — | — | EP | claimed |
| US-6204388-B1 | USING BLOCKING AGENT | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2001-03-20 | — | — | US | claimed |
| EP-1058679-A1 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO AND ANALOGUES THEROF | Sloan-Kettering Institute For Cancer Research (US) | 2000-12-13 | — | — | EP | claimed |
| EP-0977563-A1 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF | Sloan-Kettering Institute For Cancer Research (US) | 2000-02-09 | — | — | EP | claimed |
| WO-1999043653-A1 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO AND ANALOGUES THEROF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1999-09-02 | — | — | WO | claimed |
| WO-1999001124-A9 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF | SLOAN KETTERING INST CANCER (US) | 1999-05-14 | — | — | WO | claimed |
| WO-1999001124-A1 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1999-01-14 | — | — | WO | claimed |