Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.30 |
| ▸ | MELK | Q14680 | 1/20 | 0.30 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4402264 | 0.79 | RAB9A (0.41) | SCDNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL2580463 | 0.79 | NPC1 (0.40) | SCDNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL18857267 | 0.74 | PDPK1 (0.43) | SCDNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL18237571 | 0.74 | TLR8 (0.37) | SCDNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL28561318 | 0.73 | SMN1; SMN2 (0.47) | SCDNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL12154294 | 0.70 | RAB9A (0.43) | NPC1RAB9ASMN1; SMN2MAPTPARP1 | |
| SCHEMBL792405 | 0.69 | TYK2 (0.45) | SCDNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL23996116 | 0.68 | PDPK1 (0.35) | SCDPDPK1PARP1 | |
| SCHEMBL793351 | 0.65 | TYK2 (0.47) | SCDJAK2 | |
| SCHEMBL2439614 | 0.64 | PARP1 (0.34) | SCDNPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089397-B1 | 5- [4- (AZETIDIN-3-YL0XY) -PHENYL]-2-PHENYL-5H-THIAZ0L0 [5,4-C]PYRIDIN-4-0NE DERIVATIVES AND THEIR USE AS MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2012-08-29 | — | — | EP | disclosed |