Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 8/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12074825 | 0.93 | MAPT (0.54) | MAPTMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL12075204 | 0.91 | MAPT (0.53) | MAPTMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL12075408 | 0.91 | MAPT (0.52) | MAPTMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL12074829 | 0.89 | MAPT (0.54) | MAPTMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL14148253 | 0.89 | MAPT (0.55) | MAPTMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL14148280 | 0.89 | MAPT (0.55) | MAPTMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL12074827 | 0.88 | MAPT (0.51) | MAPTMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL12075210 | 0.88 | MAPT (0.54) | MAPTMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL14148236 | 0.88 | NUDT1 (0.50) | MAPTMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL1474621 | 0.88 | KDR (0.58) | MAPTMEN1KMT2APOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125780-B1 | SUBSTITUTED HETEROCYCLES AND METHODS OF USE | AMGEN INC (US) | 2012-08-29 | — | — | EP | disclosed |
| WO-2008079294-A1 | SUBSTITUTED HETEROCYCLES AND METHODS OF USE | AMGEN INC. (US) | 2008-07-03 | — | — | WO | disclosed |