⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11841381 | 0.66 | — | — | |
| SCHEMBL7321 | 0.66 | — | — | |
| Hydrochloric Acid SCHEMBL3855161 | 0.64 | CA12 (0.38) | — | |
| SCHEMBL13434243 | 0.64 | SMN1; SMN2 (0.39) | — | |
| SCHEMBL16607618 | 0.64 | SMN1; SMN2 (0.39) | — | |
| Hydrochloric Acid SCHEMBL5012159 | 0.64 | — | — | |
| SCHEMBL37779 | 0.62 | — | — | |
| SCHEMBL27693198 | 0.62 | CA12 (0.36) | — | |
| SCHEMBL22188744 | 0.62 | — | — | |
| SCHEMBL1208235 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020026053-A1 | Novel 3-(substituted) -2- indolinones compounds and use thereof as inhibitors of protein kinase activity | TANG PENG CHO (US) | 2002-02-28 | — | — | US | claimed |
| US-20010007033-A1 | Novel 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity | SUGEN, INC. | 2001-07-05 | — | — | US | claimed |
| CN-108794485-B | Toll-like receptor modulators, pharmaceutical composition, preparation method and application thereof | 北京施安泰医药技术开发有限公司 | 2020-04-24 | — | — | CN | disclosed |
| CN-108794485-A | A kind of toll samples receptor modulators, its pharmaceutical composition, preparation method and purposes | 北京施安泰医药技术开发有限公司 | 2018-11-13 | — | — | CN | disclosed |
| CN-102596228-A | Neuropeptide-2 receptor (Y-2R) agonists | HOFFMANN LA ROCHE | 2012-07-18 | — | — | CN | disclosed |
| CN-102202681-A | Neuropeptide-2 receptor (Y-2R) agonists and uses thereof | HOFFMANN LA ROCHE | 2011-09-28 | — | — | CN | disclosed |
| CN-102159589-A | Neuropeptide-2 receptor (y-2r) agonists and uses thereof | HOFFMANN LA ROCHE | 2011-08-17 | — | — | CN | disclosed |
| US-20110044938-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | NYCOMED GMBH (DE) | 2011-02-24 | — | — | US | disclosed |
| EP-2051974-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | 4SC AG (DE) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008020045-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | 4SC AG (DE) | 2008-02-21 | — | — | WO | disclosed |
| CN-1681823-A | Furoisoquinoline derivative and its application | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2005-10-12 | — | — | CN | disclosed |
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |
| US-20020026053-A1 | Novel 3-(substituted) -2- indolinones compounds and use thereof as inhibitors of protein kinase activity | TANG PENG CHO (US) | 2002-02-28 | — | — | US | disclosed |
| US-20010007033-A1 | Novel 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity | SUGEN, INC. | 2001-07-05 | — | — | US | disclosed |
| US-6133305-A | PREVENTION AND TREATMENT OF PROTEIN KINASE RELATED DISORDERS SUCH AS CANCER | SUGEN, INC. (US) | 2000-10-17 | — | — | US | disclosed |