SCHEMBL12083845

SCHEMBL12083845

c1ccc(N(N=C2c3ccccc3-c3ccccc32)c2ccccc2)cc1

nearest known ligand 0.55

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ LRRK2 Q5S007 9/20 0.55
▸ ALDH1A1 P00352 5/20 0.46
▸ ALOX15 P16050 1/20 0.46
▸ KMT2A Q03164 5/20 0.42
▸ MEN1 O00255 4/20 0.42
▸ L3MBTL1 Q9Y468 3/20 0.35
▸ MAPT P10636 2/20 0.35
▸ TDP1 Q9NUW8 2/20 0.35
▸ MAPK1 P28482 2/20 0.35
▸ RAB9A P51151 2/20 0.35
▸ POLB P06746 1/20 0.34
▸ RECQL P46063 1/20 0.34
▸ TSHR P16473 1/20 0.33
▸ ATM Q13315 1/20 0.33
▸ HSD17B10 Q99714 1/20 0.33
▸ NPC1 O15118 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13940935 0.80 LRRK2 (0.43) LRRK2ALDH1A1ALOX15KMT2AMEN1
SCHEMBL13526108 0.78 CDK5 (0.53) LRRK2ALDH1A1ALOX15KMT2AMEN1
Hydrochloric Acid SCHEMBL9218469 0.77 CDK5 (0.50) LRRK2ALDH1A1ALOX15KMT2AMEN1
SCHEMBL21327613 0.74 DEPTOR (0.48) LRRK2ALDH1A1ALOX15KMT2AMEN1
SCHEMBL8499576 0.72 LRRK2 (1.00) LRRK2KMT2AMEN1RAB9APOLB
SCHEMBL8499572 0.72 LRRK2 (1.00) LRRK2KMT2AMEN1RAB9APOLB
SCHEMBL31290736 0.66 MEN1 (0.57) ALDH1A1ALOX15KMT2AMEN1L3MBTL1
Benzene SCHEMBL27898037 0.66 MEN1 (0.57) ALDH1A1ALOX15KMT2AMEN1L3MBTL1
SCHEMBL3907869 0.64 KMT2A (0.59) ALDH1A1KMT2AMEN1L3MBTL1MAPT
SCHEMBL8829009 0.64 ALDH1A1 (0.55) LRRK2ALDH1A1ALOX15KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8257891-B2 Electrophotographic photoconductor, process cartridge and image forming apparatus RICOH COMPANY, LTD. (JP) 2012-09-04 — — US disclosed
US-8257891-B2 Electrophotographic photoconductor, process cartridge and image forming apparatus RICOH COMPANY, LTD. (JP) 2012-09-04 — — US disclosed
US-20100178074-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, PROCESS CARTRIDGE AND IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2010-07-15 — — US disclosed
US-20100178074-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, PROCESS CARTRIDGE AND IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2010-07-15 — — US disclosed
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