Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.57 |
| ▸ | BTK | Q06187 | 12/20 | 0.57 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.54 |
| ▸ | PAK4 | O96013 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12085408 | 0.90 | IRAK4 (0.53) | JAK3BTKIRAK4PAK4 | |
| SCHEMBL12085486 | 0.88 | JAK3 (0.56) | JAK3BTKIRAK4PAK4SYK | |
| SCHEMBL12085376 | 0.83 | JAK3 (0.61) | JAK3BTKIRAK4PAK4SYK | |
| SCHEMBL4377709 | 0.82 | JAK3 (0.61) | JAK3BTKIRAK4PAK4SYK | |
| SCHEMBL4381539 | 0.81 | JAK3 (0.60) | JAK3BTKIRAK4PAK4SYK | |
| SCHEMBL4382922 | 0.81 | JAK3 (0.59) | JAK3BTKIRAK4PAK4SYK | |
| SCHEMBL1019356 | 0.80 | SYK (0.62) | JAK3BTKIRAK4PAK4SYK | |
| SCHEMBL14547700 | 0.80 | PAK4 (0.53) | JAK3BTKIRAK4PAK4 | |
| SCHEMBL12085334 | 0.80 | JAK3 (0.63) | JAK3BTKIRAK4PAK4SYK | |
| SCHEMBL4302796 | 0.80 | JAK3 (0.63) | JAK3BTKIRAK4PAK4SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139581-B2 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-20130029944-A1 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-01-31 | — | — | US | disclosed |
| US-8258144-B2 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-09-04 | — | — | US | disclosed |
| US-20090298823-A1 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130029944-A1 | INHIBITORS OF PROTEIN KINASES | SYK, BTK, JAK2 | JAK3 6/4885BTK 2/4885IRAK4 42/4885 |
| US-20090298823-A1 | Inhibitors of protein kinases | SYK, BTK, JAK2 | JAK3 6/4885BTK 2/4885IRAK4 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.