Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 13/20 | 0.60 |
| ▸ | CCNE1 | P24864 | 13/20 | 0.60 |
| ▸ | CDK2 | P24941 | 13/20 | 0.60 |
| ▸ | DBF4 | Q9UBU7 | 13/20 | 0.60 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | QPCT | Q16769 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | CLK1 | P49759 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7946423 | 0.75 | CDC7 (1.00) | CDC7CCNE1CDK2DBF4GSK3B | |
| SCHEMBL1960827 | 0.70 | CDC7 (0.57) | CDC7CCNE1CDK2DBF4GSK3B | |
| SCHEMBL14335342 | 0.69 | CDC7 (0.65) | CDC7CCNE1CDK2DBF4ALK | |
| SCHEMBL12506922 | 0.68 | CDC7 (0.56) | CDC7CCNE1CDK2DBF4GSK3B | |
| SCHEMBL12550864 | 0.67 | CDC7 (0.53) | CDC7CCNE1CDK2DBF4GSK3B | |
| SCHEMBL1551968 | 0.66 | CDC7 (0.52) | CDC7CCNE1CDK2DBF4GSK3B | |
| SCHEMBL1958965 | 0.65 | CDC7 (0.53) | CDC7CCNE1CDK2DBF4GSK3B | |
| SCHEMBL12507119 | 0.65 | CDC7 (0.78) | CDC7CCNE1CDK2DBF4GSK3B | |
| SCHEMBL3491210 | 0.65 | GSK3B (1.00) | CDC7CCNE1CDK2DBF4GSK3B | |
| SCHEMBL1557178 | 0.61 | CDC7 (0.74) | CDC7CCNE1CDK2DBF4GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303879-B1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-09-05 | — | — | EP | disclosed |