Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 18/20 | 1.00 |
| ▸ | CDK2 | P24941 | 18/20 | 1.00 |
| ▸ | CCNE1 | P24864 | 16/20 | 1.00 |
| ▸ | DBF4 | Q9UBU7 | 16/20 | 1.00 |
| ▸ | CLK1 | P49759 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 3/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | PRKACA | P17612 | 2/20 | 0.53 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.50 |
| ▸ | CDK9 | P50750 | 3/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1557178 | 0.85 | CDC7 (0.74) | CDC7CDK2CCNE1DBF4DYRK1A | |
| SCHEMBL7956178 | 0.85 | CDC7 (1.00) | CDC7CDK2CCNE1DBF4GSK3B | |
| SCHEMBL14335342 | 0.79 | CDC7 (0.65) | CDC7CDK2CCNE1DBF4 | |
| SCHEMBL415716 | 0.77 | CDC7 (0.62) | CDC7CDK2CCNE1DBF4CLK1 | |
| SCHEMBL8940377 | 0.76 | CDC7 (0.78) | CDC7CDK2CCNE1DBF4CLK1 | |
| SCHEMBL12086563 | 0.75 | CDC7 (0.60) | CDC7CDK2CCNE1DBF4CLK1 | |
| SCHEMBL12409357 | 0.75 | CDC7 (0.67) | CDC7CDK2CCNE1DBF4CCNT1 | |
| SCHEMBL1960827 | 0.73 | CDC7 (0.57) | CDC7CDK2CCNE1DBF4GSK3B | |
| SCHEMBL12506922 | 0.72 | CDC7 (0.56) | CDC7CDK2CCNE1DBF4GSK3B | |
| SCHEMBL2179323 | 0.72 | CDC7 (0.69) | CDC7CDK2CCNE1DBF4CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8466170-B2 | 7-azaindole derivatives | MERCK PATENT GMBH (DE) | 2013-06-18 | — | — | US | disclosed |
| EP-2303879-B1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-09-05 | — | — | EP | disclosed |
| US-20110166175-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-07-07 | — | — | US | disclosed |
| WO-2010020308-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166175-A1 | 7-AZAINDOLE DERIVATIVES | JAK3, AZI2, MYLK2 | CDC7 250/4885CDK2 111/4885CCNE1 187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.