Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 20/20 | 0.79 |
| ▸ | CXCR1 | P25024 | 10/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13479561 | 1.00 | CXCR2 (0.79) | CXCR2CXCR1 | |
| SCHEMBL12262348 | 0.89 | CXCR2 (0.84) | CXCR2CXCR1 | |
| SCHEMBL14511214 | 0.89 | CXCR2 (0.86) | CXCR2CXCR1 | |
| SCHEMBL12262371 | 0.89 | CXCR2 (0.77) | CXCR2CXCR1 | |
| SCHEMBL12576503 | 0.88 | CXCR2 (0.81) | CXCR2CXCR1 | |
| SCHEMBL12576494 | 0.88 | CXCR2 (0.81) | CXCR2CXCR1 | |
| SCHEMBL12576505 | 0.88 | CXCR2 (0.81) | CXCR2CXCR1 | |
| SCHEMBL12576506 | 0.88 | CXCR2 (0.85) | CXCR2CXCR1 | |
| SCHEMBL12576508 | 0.88 | CXCR2 (0.85) | CXCR2CXCR1 | |
| SCHEMBL12262251 | 0.88 | CXCR2 (1.00) | CXCR2CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539678-B1 | 3,4-DI-SUBSTITUTED CYCLOBUTENE-1, 2-DIONES AS CXC-CHEMOKINE RECEPTOR LIGANDS | MERCK SHARP & DOHME (US) | 2012-09-05 | — | — | EP | disclosed |
| EP-1381590-B1 | 3,4-DI-SUBSTITUTED CYCLOBUTENE-1,2-DIONES AS CXC-CHEMOKINE RECEPTOR LIGANDS | SCHERING CORP (US) | 2007-06-20 | — | — | EP | disclosed |