⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18472350 | 1.00 | — | — | |
| SCHEMBL12151235 | 1.00 | — | — | |
| SCHEMBL13995764 | 0.73 | — | — | |
| SCHEMBL12735990 | 0.71 | — | — | |
| SCHEMBL10578538 | 0.71 | — | — | |
| SCHEMBL12140443 | 0.71 | — | — | |
| SCHEMBL15925932 | 0.70 | SPHK1 (0.32) | — | |
| SCHEMBL12620348 | 0.69 | — | — | |
| SCHEMBL158239 | 0.69 | CYP1A2 (0.31) | — | |
| SCHEMBL1503804 | 0.69 | CYP1A2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11737992-B2 | Sphingosine kinase Type 1 inhibitors and uses thereof | ENZO THERAPEUTICS, INC. (US) | 2023-08-29 | — | — | US | disclosed |
| US-9974758-B2 | Sphingosine kinase type 1 inhibitors and uses thereof | ENZO THERAPEUTICS, INC. (US) | 2018-05-22 | — | — | US | disclosed |
| US-9828349-B2 | 1-aryl-1-hydroxy-2,3-diamino-propyl amines, 1-heteroaryl-1-hydroxy-2,3-diamino-propyl amines and related compounds having analgesic and/or immuno stimulant activity | EXONHIT THERAPEUTICS SA (FR) | 2017-11-28 | — | — | US | disclosed |
| US-20160317472-A1 | Sphingosine Kinase Type 1 Inhibitors and Uses Thereof | ENZO THERAPEUTICS, INC. C/O ENZO BIOCHEM, INC. (US) | 2016-11-03 | — | — | US | disclosed |
| US-9399628-B2 | 1-aryl-1-hydroxy-2,3-diamino-propyl amines, 1-heteroaryl-1-hydroxy-2,3-diamino-propyl amines and related compounds having analgesic and/or immuno stimulant activity | ALLERGAN, INC. (US) | 2016-07-26 | — | — | US | disclosed |
| US-9388121-B2 | Sphingosine kinase type 1 inhibitors | ENZO THERAPEUTICS, INC. (US) | 2016-07-12 | — | — | US | disclosed |
| US-9314466-B2 | Methods for treating cognitive disorders using 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds | ALLERGAN, INC. (US) | 2016-04-19 | — | — | US | disclosed |
| US-20160083371-A1 | 1-ARYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES, 1-HETEROARYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES AND RELATED COMPOUNDS HAVING ANALGESIC AND/OR IMMUNO STIMULANT ACTIVITY | EXONHIT THERAPEUTICS SA (FR) | 2016-03-24 | — | — | US | disclosed |
| US-9278943-B2 | Methods of using as analgesics 1-benzyl-1-hydroxy-2, 3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds | EXONHIT THERAPEUTICS SA (FR) | 2016-03-08 | — | — | US | disclosed |
| US-20160051555-A9 | METHODS FOR TREATING COGNITIVE DISORDERS USING 1-BENZYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES, 3-BENZYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS | ALLERGAN, INC. (US) | 2016-02-25 | — | — | US | disclosed |
| US-8372888-B2 | Sphingosine kinase type 1 inhibitors, compositions and processes for using same | ENZO THERAPEUTICS, INC. (US) | 2013-02-12 | — | — | US | disclosed |
| US-8314151-B2 | Sphingosine kinase type 1 inhibitors, and processes for using same | ENZO THERAPEUTICS, INC. (US) | 2012-11-20 | — | — | US | disclosed |
| US-20120237448-A9 | SPHINGOSINE KINASE TYPE 1 INHIBITORS, AND PROCESSES FOR USING SAME | VIRGINIA COMMONWEALTH UNIVERSITY | 2012-09-20 | — | — | US | disclosed |
| US-20120225881-A1 | METHODS OF USING AS ANALGESICS 1-BENZYL-1-HYDROXY-2, 3-DIAMINO-PROPYL AMINES, 3-BENZYL-3-HYRDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS | ALLERGAN, INC. | 2012-09-06 | — | — | US | disclosed |
| US-8013000-B2 | 3-heteroaryl-3-hydroxy-2-amino-propyl amines and related compounds having analgesic and/or immuno stimlant activity | ALLERGAN, INC. (US) | 2011-09-06 | — | — | US | disclosed |
| US-20100278741-A1 | Novel compositions including sphingosine kinase type 1 inhibitors, and processes for using same | ENZO THERAPEUTICS, INC. C/O ENZO BIOCHEM, INC. | 2010-11-04 | — | — | US | disclosed |
| US-20100190792-A1 | METHODS FOR TREATING COGNITIVE DISORDERS USING 1-BENZYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES, 3-BENZYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS | ALLERGAN, INC | 2010-07-29 | — | — | US | disclosed |
| US-20100035959-A1 | Novel sphingosine kinase type 1 inhibitors, compositions and processes for using same | ENZO THERAPEUTICS, INC.C/O ENZO BIOCHEM, INC. (US) | 2010-02-11 | — | — | US | disclosed |
| US-20090088433-A1 | METHODS OF USING AS ANALGESICS 1-BENZYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES, 3-BENZYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS | ALLERGAN, INC. | 2009-04-02 | — | — | US | disclosed |
| US-20080312236-A1 | 3-Heteroaryl-3-Hydroxy-2-Amino-Propyl Amines And Related Compounds Having Analgesic And/Or Immuno Stimlant Activity | EXONHIT THERAPEUTICS SA (FR) | 2008-12-18 | — | — | US | disclosed |