Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL158239 | 0.87 | CYP1A2 (0.31) | SPHK1 | |
| SCHEMBL1503804 | 0.87 | CYP1A2 (0.31) | SPHK1 | |
| SCHEMBL5018437 | 0.85 | SPHK1 (0.30) | SPHK1 | |
| SCHEMBL8060263 | 0.82 | CHRNB2 (0.35) | SPHK1SMN1; SMN2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL222671 | 0.79 | SPHK1 (0.50) | SPHK1SMN1; SMN2 | |
| SCHEMBL209164 | 0.79 | SPHK1 (0.50) | SPHK1SMN1; SMN2 | |
| SCHEMBL222670 | 0.79 | SPHK1 (0.50) | SPHK1SMN1; SMN2 | |
| SCHEMBL15257477 | 0.79 | SPHK1 (0.32) | SPHK1SMN1; SMN2 | |
| SCHEMBL8823464 | 0.76 | SPHK1 (0.40) | SPHK1 | |
| SCHEMBL12140443 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114906-B1 | 2-AMINOOXAZOLINES AS TAAR1 LIGANDS FOR CNS DISORDERS | HOFFMANN LA ROCHE (CH) | 2014-08-06 | — | — | EP | disclosed |