Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 15/20 | 0.36 |
| ▸ | CCND1 | P24385 | 15/20 | 0.36 |
| ▸ | CCND2 | P30279 | 15/20 | 0.36 |
| ▸ | CCND3 | P30281 | 15/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.33 |
| ▸ | CDK1 | P06493 | 3/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4135677 | 0.80 | MTNR1A (0.40) | CDK4CCND1CCND2CCND3 | |
| SCHEMBL12090783 | 0.80 | CDK4 (0.46) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL12090831 | 0.78 | CYP1A2 (0.39) | LMNAHPGDMEN1KMT2A | |
| SCHEMBL12090918 | 0.78 | KDM4E (0.34) | KDM4ELMNAHPGDCDK4CCND1 | |
| SCHEMBL3847343 | 0.76 | CDC7 (0.35) | CDK4CCND1CCND2CCND3 | |
| SCHEMBL19212821 | 0.76 | CDK4 (0.43) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL4136624 | 0.73 | CDK4 (0.44) | HPGDCDK4CCND1CCND2CCND3 | |
| SCHEMBL19212769 | 0.72 | CDK4 (0.33) | CDK4CCND1CCND2CCND3ADORA1 | |
| SCHEMBL12090848 | 0.72 | KMT2A (0.42) | KDM4ELMNAGAAHPGDHTT | |
| SCHEMBL2798381 | 0.70 | BTK (0.41) | KDM4EHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367831-B2 | Heterocyclic compound or salt thereof and intermediate thereof | TOYAMA CHEMICAL CO., LTD. (JP) | 2013-02-05 | — | — | US | disclosed |
| US-20120226035-A1 | NOVEL HETEROCYCLIC COMPOUND OR SALT THEREOF AND INTERMEDIATE THEREOF | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2012-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120226035-A1 | NOVEL HETEROCYCLIC COMPOUND OR SALT THEREOF AND INTERMEDIATE THEREOF | IKZF3, ZC3HAV1L, CXXC5 | KDM4E 1786/4885LMNA 2461/4885GAA 4567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.