Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | POLB | P06746 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12882628 | 1.00 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL12882842 | 0.91 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL1207055 | 0.91 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL12895428 | 0.90 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL1219195 | 0.90 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL12883785 | 0.90 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL1208352 | 0.90 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL1208904 | 0.90 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL12882703 | 0.89 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL1207619 | 0.89 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110044938-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | NYCOMED GMBH (DE) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110044938-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | BAX, BCL2, BAD | ALDH1A1 316/4885SMN1; SMN2 2135/4885HPGD 2097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.