SCHEMBL12095349

SCHEMBL12095349

COc1c(F)cc(C(=O)N[C@]2(C(=O)O)CC[C@H](C)CC2)cc1OCCc1cccc(CCO)c1

nearest known ligand 0.58

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ LPAR1 Q92633 6/20 0.58
▸ GPR132 Q9UNW8 2/20 0.46
▸ F10 P00742 2/20 0.37
▸ CYP4F2 P78329 1/20 0.34
▸ CYP4A11 Q02928 1/20 0.34
▸ CNR1 P21554 2/20 0.34
▸ CNR2 P34972 2/20 0.34
▸ GRIK2 Q13002 1/20 0.33
▸ SLC6A5 Q9Y345 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12095348 1.00 LPAR1 (0.58) LPAR1GPR132F10CYP4F2CYP4A11
SCHEMBL12095350 1.00 LPAR1 (0.58) LPAR1GPR132F10CYP4F2CYP4A11
SCHEMBL6845254 0.92 LPAR1 (0.51) LPAR1GPR132F10CYP4F2CYP4A11
SCHEMBL13276430 0.92 LPAR1 (0.51) LPAR1GPR132F10CYP4F2CYP4A11
SCHEMBL13276433 0.92 LPAR1 (0.51) LPAR1GPR132F10CYP4F2CYP4A11
SCHEMBL1809808 0.91 LPAR1 (0.61) LPAR1GPR132CNR2SLC6A5
SCHEMBL1560963 0.87 LPAR1 (0.57) LPAR1GPR132
SCHEMBL1813119 0.86 LPAR1 (0.76) LPAR1GPR132GRIK2
SCHEMBL1813121 0.86 LPAR1 (0.76) LPAR1GPR132GRIK2
SCHEMBL1813117 0.86 LPAR1 (0.76) LPAR1GPR132GRIK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120264790-A1 ACYLAMINO-SUBSTITUTED CYCLIC CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS SANOFI (FR) 2012-10-18 — — US disclosed
EP-2496556-A1 ACYLAMINO-SUBSTITUTED CYCLIC CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS SANOFI (FR) 2012-09-12 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120264790-A1 ACYLAMINO-SUBSTITUTED CYCLIC CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS LPAR2, LIPG, EDF1 LPAR1 4/4885GPR132 518/4885F10 112/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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