Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | UTS2R | Q9UKP6 | 8/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11604596 | 0.82 | UTS2R (0.46) | HPGDUTS2R | |
| SCHEMBL11489460 | 0.79 | UTS2R (0.45) | HPGDUTS2RALDH1A1L3MBTL1 | |
| SCHEMBL11494123 | 0.72 | UTS2R (0.47) | UTS2RNPSR1 | |
| SCHEMBL11566392 | 0.72 | UTS2R (0.49) | UTS2RL3MBTL1GAA | |
| SCHEMBL11494057 | 0.71 | POLB (0.41) | UTS2RMAPK1ALDH1A1NPSR1POLB | |
| SCHEMBL31265268 | 0.71 | MEN1 (0.47) | MEN1KMT2AMITFMAPK1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL11564213 | 0.70 | UTS2R (0.48) | UTS2RL3MBTL1 | |
| SCHEMBL11489692 | 0.69 | UTS2R (0.46) | UTS2RALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL18435278 | 0.69 | MEN1 (0.48) | MEN1KMT2AMITFHPGDMAPK1 | |
| SCHEMBL27583456 | 0.69 | MEN1 (0.48) | MEN1KMT2AMITFHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9585865-B2 | Small molecule modulators of the cold and menthol receptor TRPM8 | B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG (DE) | 2017-03-07 | — | — | US | disclosed |
| US-9585865-B2 | Small molecule modulators of the cold and menthol receptor TRPM8 | B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG (DE) | 2017-03-07 | — | — | US | disclosed |
| US-9585865-B2 | Small molecule modulators of the cold and menthol receptor TRPM8 | B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG (DE) | 2017-03-07 | — | — | US | disclosed |
| EP-2683352-B1 | SMALL MOLECULE MODULATORS OF THE COLD AND MENTHOL RECEPTOR TRPM8 | BRAIN BIOTECHNOLOGY RES & INFORMATION NETWORK AG (DE) | 2016-10-26 | — | — | EP | disclosed |
| EP-2683352-B1 | SMALL MOLECULE MODULATORS OF THE COLD AND MENTHOL RECEPTOR TRPM8 | BRAIN BIOTECHNOLOGY RES & INFORMATION NETWORK AG (DE) | 2016-10-26 | — | — | EP | disclosed |
| US-20150094365-A1 | SMALL MOLECULE MODULATORS OF THE COLD AND MENTHOL RECEPTOR TRPM8 | B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG (DE) | 2015-04-02 | — | — | US | disclosed |
| US-20150094365-A1 | SMALL MOLECULE MODULATORS OF THE COLD AND MENTHOL RECEPTOR TRPM8 | B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG (DE) | 2015-04-02 | — | — | US | disclosed |
| US-20150094365-A1 | SMALL MOLECULE MODULATORS OF THE COLD AND MENTHOL RECEPTOR TRPM8 | B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG (DE) | 2015-04-02 | — | — | US | disclosed |
| US-20130345300-A1 | SMALL MOLECULE MODULATORS OF THE COLD AND MENTHOL RECEPTOR TRPM8 | B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG (DE) | 2013-12-26 | — | — | US | disclosed |
| WO-2012120099-A2 | SMALL MOLECULE MODULATORS OF THE COLD AND MENTHOL RECEPTOR TRPM8 | B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG (DE) | 2012-09-13 | — | — | WO | disclosed |
| EP-2497458-A1 | Small molecule modulators of the cold and menthol receptor TRPM8 | B.R.A.I.N. Biotechnology Research And Information Network AG (DE) | 2012-09-12 | — | — | EP | disclosed |
| EP-2497458-A1 | Small molecule modulators of the cold and menthol receptor TRPM8 | B.R.A.I.N. Biotechnology Research And Information Network AG (DE) | 2012-09-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130345300-A1 | SMALL MOLECULE MODULATORS OF THE COLD AND MENTHOL RECEPTOR TRPM8 | TRPM8, TRPM7, TRPM4 | MEN1 454/4885KMT2A 901/4885MITF 341/4885 |
| US-20150094365-A1 | SMALL MOLECULE MODULATORS OF THE COLD AND MENTHOL RECEPTOR TRPM8 | TRPM8, TRPM7, TRPM4 | MEN1 454/4885KMT2A 901/4885MITF 341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.