Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 11/20 | 0.35 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.33 |
| ▸ | ASPH | Q12797 | 1/20 | 0.33 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2582486 | 0.89 | EGLN1 (0.43) | EGLN1HIF1ABBOX1ASPHKDM8 | |
| SCHEMBL2579364 | 0.77 | EGLN1 (0.41) | EGLN1HIF1A | |
| SCHEMBL2583574 | 0.77 | EGLN1 (0.57) | EGLN1HIF1ABBOX1ASPHKDM8 | |
| SCHEMBL2583556 | 0.77 | EGLN1 (0.45) | EGLN1HIF1A | |
| SCHEMBL2580152 | 0.76 | GABRA1 (0.41) | EGLN1HIF1A | |
| SCHEMBL2579371 | 0.75 | EGLN1 (0.41) | EGLN1HIF1A | |
| SCHEMBL2582041 | 0.75 | TNF (0.41) | EGLN1HIF1A | |
| SCHEMBL2581909 | 0.74 | HIF1A (0.36) | EGLN1HIF1A | |
| SCHEMBL2583357 | 0.74 | EGLN1 (0.40) | EGLN1HIF1ABBOX1ASPHKDM8 | |
| SCHEMBL12101568 | 0.72 | HIF1A (0.41) | EGLN1HIF1ACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097416-B1 | AZAQUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | AMGEN INC (US) | 2012-09-12 | — | — | EP | disclosed |