Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP21A2 | P08686 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1154666 | 0.85 | IDO1 (0.42) | TDP1KDM4EALDH1A1ALOX5GAA | |
| SCHEMBL19383083 | 0.82 | TDP1 (0.36) | TDP1KDM4EALDH1A1ALOX5GAA | |
| SCHEMBL22169009 | 0.80 | CA2 (0.38) | TDP1KDM4EALDH1A1ALOX5GAA | |
| SCHEMBL12101004 | 0.80 | TDP1 (0.34) | TDP1KDM4EALDH1A1ALOX5GAA | |
| SCHEMBL1246772 | 0.80 | TDP1 (0.34) | TDP1KDM4EALDH1A1ALOX5GAA | |
| SCHEMBL27830244 | 0.80 | TDP1 (0.34) | TDP1KDM4EALDH1A1ALOX5GAA | |
| SCHEMBL14270585 | 0.77 | IDO1 (0.48) | IDO1DAO | |
| SCHEMBL63871 | 0.77 | TDP1 (0.53) | TDP1KDM4EALDH1A1ALOX5GAA | |
| SCHEMBL1834422 | 0.76 | DAO (0.39) | TDP1KDM4EALDH1A1ALOX5GAA | |
| SCHEMBL8417016 | 0.76 | PTGS1 (0.37) | TDP1KDM4EALDH1A1ALOX5GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242759-B1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2012-09-12 | — | — | EP | disclosed |