Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.60 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3587632 | 0.89 | MET (0.62) | METPDE3BPDE3A | |
| SCHEMBL12049212 | 0.88 | MET (0.53) | MET | |
| SCHEMBL12049818 | 0.81 | MET (0.49) | METPDE3BPDE3A | |
| SCHEMBL12049211 | 0.81 | MET (0.54) | METPDE3BPDE3A | |
| SCHEMBL12049823 | 0.79 | MET (0.47) | METPDE3BPDE3A | |
| SCHEMBL14198925 | 0.79 | MET (0.65) | MET | |
| SCHEMBL3593536 | 0.79 | MET (0.51) | METPDE3BPDE3A | |
| SCHEMBL12049836 | 0.78 | MET (0.46) | METPDE3BPDE3A | |
| SCHEMBL12049185 | 0.78 | MET (0.46) | METPDE3BPDE3A | |
| SCHEMBL12049191 | 0.77 | MET (0.49) | METPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081937-B1 | TRIAZOLOPYRIDAZINE PROTEIN KINASE MODULATORS | SGX PHARMACEUTICALS INC (US) | 2012-09-12 | — | — | EP | disclosed |