Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 16/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2578845 | 0.89 | EGLN1 (0.51) | EGLN1HIF1AMEN1NPC1RAB9A | |
| SCHEMBL2576963 | 0.86 | HIF1A (0.48) | EGLN1HIF1AMEN1NPC1RAB9A | |
| SCHEMBL12101654 | 0.85 | EGLN1 (0.58) | EGLN1HIF1A | |
| SCHEMBL2577063 | 0.85 | HIF1A (0.44) | EGLN1HIF1A | |
| SCHEMBL12172226 | 0.84 | EGLN1 (0.43) | EGLN1HIF1ARAB9AKMT2AKDM4E | |
| SCHEMBL2582034 | 0.84 | HIF1A (0.48) | EGLN1HIF1AMEN1NPC1RAB9A | |
| SCHEMBL337546 | 0.82 | EGLN1 (0.50) | EGLN1HIF1AMEN1NPC1RAB9A | |
| SCHEMBL2587881 | 0.82 | CALCA (0.42) | EGLN1HIF1AKDM4E | |
| SCHEMBL2580935 | 0.82 | EGLN1 (0.42) | EGLN1HIF1A | |
| SCHEMBL337574 | 0.80 | EGLN1 (0.49) | EGLN1HIF1AMEN1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097416-B1 | AZAQUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | AMGEN INC (US) | 2012-09-12 | — | — | EP | disclosed |