CALCA — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL178848	0.86	17/20
Zavegepant (SCHEMBL107428)	0.82	16/20
Zavegepant (SCHEMBL142472)	0.82	16/20
SCHEMBL178841	0.71	16/20
SCHEMBL1394519	1.00	13/20
SCHEMBL1393877	0.80	13/20
SCHEMBL968119	0.78	13/20
SCHEMBL1394294	0.72	13/20
SCHEMBL1394306	0.71	13/20
SCHEMBL1394714	0.68	13/20
SCHEMBL1395323	0.68	13/20
SCHEMBL1819439	0.60	13/20
SCHEMBL1820308	0.60	13/20
SCHEMBL1393838	0.60	13/20
SCHEMBL1393840	0.60	13/20
SCHEMBL1394769	0.58	13/20
SCHEMBL1818102	0.53	13/20
SCHEMBL1821107	0.52	13/20
SCHEMBL1393888	0.63	12/20
SCHEMBL1394658	0.63	12/20

Clinical trials — most relevant to CALCA by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Hypersensitivity to CGRP as a Predictive Biomarker of Migraine Prevention With Erenumab	PHASE4	UNKNOWN
Decoding Pain Sensitivity in Migraine With Multimodal Brainstem-based Neurosignature	PHASE4	UNKNOWN
A Trial of Eptinezumab in Participants With Migraine and Insufficient Response to Anti-CGRP Medications	PHASE4	ACTIVE_NOT_RECRUITING
Functional Yogurt Powder Effect on Bone Health Biomarkers	PHASE3	COMPLETED
A Study to Evaluate Oral Salmon Calcitonin in the Treatment of Osteoporosis in Postmenopausal Women Taking Calcium and Vitamin D	PHASE3	COMPLETED
Safety and Efficacy of Botulinum Toxin A in Patients With Posttraumatic Headache	PHASE3	RECRUITING
A Study of Oral Calcitonin Given at Night to Healthy Postmenopausal Women	PHASE2	COMPLETED
A Study of Oral Recombinant Salmon Calcitonin (rsCT) to Prevent Postmenopausal Osteoporosis	PHASE2	COMPLETED
PTHrP(1-36) IV Dose Escalation Study	PHASE1	WITHDRAWN
Efficacy and Safety of XH02 for the Treatment of Hypoparathyroidism	EARLY_PHASE1	RECRUITING
Clinical Characteristics and Pathophysiology of Post-Traumatic Headache	nan	COMPLETED
Longitudinal Analysis of Amylin Levels in Migraine Patients Undergoing an Anti- CGRP/CGRPr Treatment	nan	NOT_YET_RECRUITING
CGRP Induced Migraine Attacks in Patients With High and Low Genetic Load	nan	COMPLETED
Effectiveness of Immersive Virtual Reality on Biomarkers and Clinical and Clinimetric Variables in Patients With Persistent Shoulder Pain	nan	COMPLETED
Induction of Migraine Attacks With Aura Using Calcitonin Gene-Related Peptide	nan	RECRUITING
Calcitonin in Needle Wash Using Electrochemiluminescence Method For Diagnosis Of Medullary Thyroid Carcinoma.	nan	COMPLETED
Stimulation-evoked Calcitonin Gene-Related Peptide (CGRP) as Biomarker of Migraine	nan	UNKNOWN
Impact of Clinical, Demographic and Laboratory Variables on Brain Natriuretic Peptide Levels	nan	WITHDRAWN
Evaluation of Microbial and Endocrinological Parameters in Dialysis Patients With Sepsis	nan	RECRUITING
Calcitonin for Treating X-linked Hypophosphatemia	nan	COMPLETED
Efficacy of Xeomin for Migraines in Patients With Traumatic Brain Injuries vs. Anomalous Health Incidents	nan	RECRUITING
The Role of Amylin in Bone Metabolism	nan	UNKNOWN
Comparison of Treximet & Imitrex as They Affect the Levels of Inflammatory Markers When the Patient is Actively Having a Migraine Headache	nan	COMPLETED
The Effect of Disease-specific Treatment on Bone Turnover Markers in Patients With Primary Aldosteronism	nan	COMPLETED
Assessment of Disease Severity, Progression and Treatment in Infected Patients Presenting to the Emergency Department	nan	COMPLETED
Effect of Osteopathic Intervention on Migraine	nan	NOT_YET_RECRUITING
Calciotropic Effects After HCG Stimulation Test	nan	COMPLETED
CRP Versus PCT as Bio-markers for Sepsis and in Guiding Antibiotics in Critically Ill Patients	nan	COMPLETED
PACAP Induced Migraine Attacks in Patients With High and Low Genetic Load	nan	COMPLETED
Human Electrophysiological Model to Quantify the CGRP-related Axon Reflex of Trigeminal Afferents	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a CALCA binder may also engage these)

Protein	Name	Similarity
CALCB	Calcitonin gene-related peptide 2	1.000	landscape →
Q9N0T3	—	1.000	Q9N0T3 →
Q9MYV1	—	0.997	Q9MYV1 →
P01256	—	0.996	P01256 →
Q99JA0	—	0.991	Q99JA0 →
Q9N0T2	—	0.984	Q9N0T2 →
Q99MP3	—	0.982	Q99MP3 →
P10093	—	0.981	P10093 →
Q75V94	—	0.979	Q75V94 →
Q9QXK8	—	0.978	Q9QXK8 →
Q75V93	—	0.976	Q75V93 →
P10286	—	0.975	P10286 →
B3IWF7	—	0.974	B3IWF7 →
Q75V95	—	0.973	Q75V95 →
Q766Y7	—	0.972	Q766Y7 →
P12968	—	0.971	P12968 →
Q862B1	—	0.970	Q862B1 →
P81564	—	0.970	P81564 →
P12760	—	0.969	P12760 →
P12967	—	0.969	P12967 →
Q805D3	—	0.968	Q805D3 →
Q766Y6	—	0.968	Q766Y6 →
P48645	—	0.968	P48645 →
P22889	—	0.968	P22889 →
P01263	—	0.967	P01263 →
P17716	—	0.967	P17716 →
P12969	—	0.966	P12969 →
P23442	—	0.966	P23442 →
P53366	—	0.965	P53366 →
P07660	—	0.965	P07660 →