Sialic Acid

Sialic Acid

SCHEMBL12108944

CC(=O)N[C@H]1C([C@H](O)[C@H](O)CO)O[C@](O)(C(=O)O)C[C@H]1O

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ NANP Q8TBE9 3/20 0.72
▸ L3MBTL1 Q9Y468 1/20 0.68
▸ NEU2 Q9Y3R4 3/20 0.47
▸ NEU4 Q8WWR8 2/20 0.47
▸ NEU3 Q9UQ49 2/20 0.47
▸ NEU1 Q99519 1/20 0.47
▸ SELL P14151 1/20 0.43
▸ SELP P16109 1/20 0.43
▸ MAG P20916 2/20 0.42
▸ SIGLEC7 Q9Y286 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sialic Acid SCHEMBL15343921 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL8503823 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL22879166 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL16549477 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL23366253 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL24274184 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL22279106 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL21067569 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL22943658 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL13703572 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9157105-B2 Biosynthesis of CMP-legionaminic acid from fructose-6-P, and respective pathway intermediates, using novel GDP-linked precursors NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2015-10-13 — — US disclosed
US-8754192-B2 Compositions comprising homogeneously glycosylated erythropoietin SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2014-06-17 — — US disclosed
US-8053410-B2 Pegylated factor VII glycoforms NOVO NORDISK HEALTH CARE A/G (CH) 2011-11-08 — — US disclosed
US-20100081786-A1 Homogeneous Erythropoietin and Other Peptides and Proteins, Methods and Intermediates for Their Preparation NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2010-04-01 — — US disclosed
US-20090048440-A1 Nucleotide Sugar Purification Using Membranes NEOSE TECHNOLOGIES, INC. (US) 2009-02-19 — — US disclosed
US-20080039373-A1 Pegylated Factor VII Glycoforms NOVO NORDISK A/S (DK) 2008-02-14 — — US disclosed
WO-2007120614-A2 HOMOGENEOUS ERYTHROPOIETIN AND OTHER PEPTIDES AND PROTEINS, METHODS AND INTERMEDIATES FOR THEIR PREPARATION SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2007-10-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090048440-A1 Nucleotide Sugar Purification Using Membranes SLC35B2, SLC35A1, GALNT1 NANP 35/4885L3MBTL1 2282/4885NEU2 24/4885
US-20100081786-A1 Homogeneous Erythropoietin and Other Peptides and Proteins, Methods and Intermediates for Their Preparation EPOR, LIFR, LNPEP NANP 3436/4885L3MBTL1 313/4885NEU2 2151/4885
US-20080039373-A1 Pegylated Factor VII Glycoforms F7, F13B, F5 NANP 247/4885L3MBTL1 1805/4885NEU2 49/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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