Sugi Predict

Sugi Predict / Targets / LNPEP

LNPEP

Leucyl-cystinyl aminopeptidase · Q9UIQ6 · LNPEP on Sugi Atlas →

24,406 patent compounds predicted against LNPEP, 11,721 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL936903 SCHEMBL936903 0.40 15/20
SCHEMBL937599 SCHEMBL937599 0.39 14/20
SCHEMBL937515 SCHEMBL937515 0.33 14/20
SCHEMBL937148 SCHEMBL937148 0.37 13/20
SCHEMBL937150 SCHEMBL937150 0.37 13/20
SCHEMBL1206766 SCHEMBL1206766 0.59 11/20
SCHEMBL936880 SCHEMBL936880 0.32 10/20
SCHEMBL1391452 SCHEMBL1391452 0.53 9/20
SCHEMBL1391454 SCHEMBL1391454 0.53 9/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL1391618) 0.50 9/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL1391619) 0.50 9/20
SCHEMBL1705658 SCHEMBL1705658 0.40 9/20
SCHEMBL345990 SCHEMBL345990 0.56 8/20
SCHEMBL1637143 SCHEMBL1637143 0.54 8/20
SCHEMBL462390 SCHEMBL462390 0.50 8/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL1391474) 0.50 8/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL1391475) 0.50 8/20
SCHEMBL771670 SCHEMBL771670 0.44 8/20
SCHEMBL774189 SCHEMBL774189 0.44 8/20
SCHEMBL763149 SCHEMBL763149 0.59 7/20

Clinical trials — most relevant to LNPEP by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Treatment Frequency Reduction in Pompe Disease PHASE4NOT_YET_RECRUITING
Effect of Renin-angiotensin-system Blockade on Urinary Free Light Chains in Patients With Type 2 Diabetes Mellitus PHASE4COMPLETED
Dose Escalation Study to Determine the Pharmacokinetics of Atazanavir Administered With RIfampicin to HIV Positive Adults on sEcond-line ART Regimen With Suppressed HIV-1 Viral Load PHASE2/PHASE3COMPLETED
Immunity and Safety of Covid-19 Synthetic Minigene Vaccine PHASE1/PHASE2RECRUITING
Long-Term TARP Vaccination Using a Multi-Epitope TARP Peptide Autologous Dendritic Cell Vaccination in Previously Vaccinated Men on NCI 09-C-0139 PHASE2COMPLETED
DEFINE - Evaluating Therapies for COVID-19 PHASE1/PHASE2COMPLETED
Polymer-lipid Particle-delivered CAR1920 mRNA CAR-T Therapy for Relapsed/Refractory B-cell Lymphoma/Leukemia PHASE2RECRUITING
NALIRIFOX (Nal-IRI Plus 5-FU/LV Plus Oxaliplatin) as First-Line Treatment for Patients With Advanced Small Intestine and Appendiceal Cancers PHASE1NOT_YET_RECRUITING
CoVID-19 Plasma in Treatment of COVID-19 Patients EARLY_PHASE1COMPLETED
Pilot Study of Neoantigen Peptides for the Treatment of Neoplasms EARLY_PHASE1COMPLETED
Pilot Study of Neoantigen Peptides and Leukine for the Treatment of Neoplasms EARLY_PHASE1UNKNOWN
Institution of an Italian Multicenter Database of Patients Affected by Diseases of Phosphate Metabolism nanNOT_YET_RECRUITING
Influence of Statins in Artery Aneurysms nanUNKNOWN
Neutral Endopeptidase for Early Detection of Acute Kidney Injury After Cardiac Surgery nanCOMPLETED
Effect of Dipeptidyl Peptidase IV After Diets in näive Type 2 Diabetic Patients nanCOMPLETED
PSMA and TARP Peptide Vaccine With Poly IC-LC Adjuvant in HLA-A2 (+) Patients With Elevated PSA After Initial Definitive Treatment nanCOMPLETED
Carboxypeptidase-G2 in Treating Nervous System Toxic Effects in Patients Given an Overdose of Intrathecal Methotrexate nanCOMPLETED
Pharmacokinetics of Low Molecular Weight Heparin in Cancer Patients nanCOMPLETED
Correlation Between Serum Markers of Unstable Plaque and Virtual Histology of Unstable Plaque Visualized by IVUS nanCOMPLETED
Ovarian Reserve and Matrix Metalloproteinases nanCOMPLETED
Foci of Tumor Heterogeneity in Diffuse Low-Grade Gliomas nanCOMPLETED
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis nanUNKNOWN
Integrated Proteomic HPLC-ESI-MS Analysis of Salivary Peptides of Preterm Newborns: a Pilot Study nanCOMPLETED
mSEPT9 Biomarker for Predicting Hepatocellular Carcinoma Occurrence in Patients With Cirrhosis nanRECRUITING
Large-scale COVID-19 Population Screening nanUNKNOWN
CIRP and Cathepsin B in Neuroinflammation After Intracerebral Hemorrhage nanNOT_YET_RECRUITING
Aminophylline to Prevent Acute Kidney Injury in Children After Cardiac Surgery nanCOMPLETED
Respiratory Cathepsins, Proteases Inhibitors and Glycosaminoglycans (GAG) in Mucopolysaccharidosis nanCOMPLETED
A Cut-off Value Study of N-terminal Brain Natriuretic Peptide （Chemiluminescence Method） nanCOMPLETED
Identification of Biomarkers Associated With Human Hepatocellular Carcinoma by SELDI nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a LNPEP binder may also engage these)

ProteinNameSimilarity
Q5RFP3 — 1.000 Q5RFP3 →
Q8C129 — 1.000 Q8C129 →
ERAP2 Endoplasmic reticulum aminopeptidase 2 1.000 landscape →
A6QPT7 — 1.000 A6QPT7 →
P97629 — 0.999 P97629 →
Q9JJ22 — 0.996 Q9JJ22 →
ERAP1 Endoplasmic reticulum aminopeptidase 1 0.996 landscape →
ENPEP Glutamyl aminopeptidase 0.992 landscape →
A0A6J2ATK2 — 0.992 A0A6J2ATK2 →
P97449 — 0.992 P97449 →
Q9EQH2 — 0.992 Q9EQH2 →
P15684 — 0.991 P15684 →
P50123 — 0.991 P50123 →
A5HUI5 — 0.990 A5HUI5 →
Q6Q4G3 — 0.990 Q6Q4G3 →
P16406 — 0.990 P16406 →
D3UW23 — 0.989 D3UW23 →
P15145 — 0.989 P15145 →
M3XFH7 — 0.989 M3XFH7 →
P79171 — 0.989 P79171 →
P79098 — 0.988 P79098 →
P15541 — 0.987 P15541 →
ANPEP Aminopeptidase N 0.986 landscape →
Q9Z218 — 0.986 Q9Z218 →
Q32LQ0 — 0.986 Q32LQ0 →
MGAM2 Probable maltase-glucoamylase 2 (Maltase-gluc 0.985 landscape →
P28843 — 0.985 P28843 →
Q6K4E7 — 0.985 Q6K4E7 →
Q8JZZ7 — 0.985 Q8JZZ7 →
Q95334 — 0.984 Q95334 →