SCHEMBL12111663

SCHEMBL12111663

FC(F)(F)c1ccccc1-c1nc2ccc(-c3ccc4nc(-c5ccccc5)c(-c5ccccc5)nc4c3)cc2nc1-c1ccccc1C(F)(F)F

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3R1 P27986 3/20 0.59
PIK3CA P42336 3/20 0.59
BACE1 P56817 1/20 0.48
KDM4E B2RXH2 5/20 0.47
ALDH1A1 P00352 4/20 0.47
L3MBTL1 Q9Y468 3/20 0.47
KMT2A Q03164 3/20 0.47
ATM Q13315 1/20 0.47
TLR9 Q9NR96 1/20 0.47
GAA P10253 3/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
NPC1 O15118 1/20 0.44
HPGD P15428 1/20 0.44
RAB9A P51151 1/20 0.44
DPP4 P27487 1/20 0.44
LMNA P02545 4/20 0.43
TRPA1 O75762 2/20 0.43
TDP1 Q9NUW8 2/20 0.42
MEN1 O00255 2/20 0.42
TRPM8 Q7Z2W7 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12111561 1.00 PIK3R1 (0.59) PIK3R1PIK3CABACE1KDM4EALDH1A1
SCHEMBL12111574 1.00 PIK3R1 (0.59) PIK3R1PIK3CABACE1KDM4EALDH1A1
SCHEMBL12111634 1.00 PIK3R1 (0.59) PIK3R1PIK3CABACE1KDM4EALDH1A1
SCHEMBL12111498 0.94 PIK3R1 (0.64) PIK3R1PIK3CABACE1KDM4EALDH1A1
SCHEMBL12595544 0.92 PIK3R1 (0.52) PIK3R1PIK3CABACE1KDM4EALDH1A1
SCHEMBL12595536 0.92 PIK3R1 (0.52) PIK3R1PIK3CABACE1KDM4EALDH1A1
SCHEMBL12595510 0.86 PIK3R1 (0.56) PIK3R1PIK3CABACE1ALDH1A1SMN1; SMN2
SCHEMBL12111668 0.81 AKT1 (0.57) PIK3R1PIK3CAKDM4EALDH1A1L3MBTL1
SCHEMBL12111564 0.81 AKT1 (0.57) PIK3R1PIK3CAKDM4EALDH1A1L3MBTL1
SCHEMBL12111632 0.81 AKT1 (0.57) PIK3R1PIK3CAKDM4EALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2113133-B1 LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE AND QUINOXALINE DERIVATIVE SEMICONDUCTOR ENERGY LAB (JP) 2013-04-24 EP disclosed
EP-2573075-A1 Light-emitting element, light-emitting device, electronic device, and quinoxaline derivative SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2013-03-27 EP disclosed
US-8362472-B2 Light-emitting element, light-emitting device, electronic device and quinoxaline derivative SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2013-01-29 US disclosed
US-8362472-B2 Light-emitting element, light-emitting device, electronic device and quinoxaline derivative SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2013-01-29 US disclosed
US-8053980-B2 Light-emitting device and electronic device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2011-11-08 US disclosed
US-8053980-B2 Light-emitting device and electronic device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2011-11-08 US disclosed
US-20110121721-A1 Light-Emitting Element, Light-Emitting Device, Electronic Device and Quinoxaline Derivative SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2011-05-26 US disclosed
US-20110121721-A1 Light-Emitting Element, Light-Emitting Device, Electronic Device and Quinoxaline Derivative SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2011-05-26 US disclosed
US-7875879-B2 Light-emitting element, light-emitting device, electronic device and quinoxaline derivative SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2011-01-25 US disclosed
US-20080231177-A1 Light-Emitting Device and Electronic Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2008-09-25 US disclosed
US-20080231177-A1 Light-Emitting Device and Electronic Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2008-09-25 US disclosed
EP-1973386-A2 Light-emitting device and electronic device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2008-09-24 EP disclosed
US-20080217608-A1 Light-Emitting Element, Light-Emitting Device, Electronic Device and Quinoxaline Derivative SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2008-09-11 US disclosed
WO-2008102713-A1 LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE AND QUINOXALINE DERIVATIVE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2008-08-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110121721-A1 Light-Emitting Element, Light-Emitting Device, Electronic Device and Quinoxaline Derivative SLC1A2, NQO1, KCNE1 PIK3R1 4882/4885PIK3CA 4186/4885BACE1 2449/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.