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Sugi Predict / Targets / KCNE1

KCNE1

Potassium voltage-gated channel subfamily E member 1 · P15382 · KCNE1 on Sugi Atlas →

38,031 patent compounds predicted against KCNE1, 24,805 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL774698 SCHEMBL774698 0.67 15/20
SCHEMBL367538 SCHEMBL367538 1.00 12/20
SCHEMBL265831 SCHEMBL265831 0.57 12/20
SCHEMBL401818 SCHEMBL401818 0.71 11/20
SCHEMBL203109 SCHEMBL203109 0.54 11/20
SCHEMBL403408 SCHEMBL403408 0.72 9/20
SCHEMBL9148 SCHEMBL9148 0.55 9/20
SCHEMBL774620 SCHEMBL774620 0.54 9/20
SCHEMBL403003 SCHEMBL403003 0.68 8/20
SCHEMBL401850 SCHEMBL401850 0.64 8/20
SCHEMBL402589 SCHEMBL402589 0.71 7/20
SCHEMBL404373 SCHEMBL404373 0.58 7/20
SCHEMBL535403 SCHEMBL535403 0.53 7/20
SCHEMBL403184 SCHEMBL403184 0.59 6/20
SCHEMBL404209 SCHEMBL404209 0.57 6/20
SCHEMBL509115 SCHEMBL509115 0.71 5/20
SCHEMBL509362 SCHEMBL509362 0.71 5/20
SCHEMBL403487 SCHEMBL403487 0.56 5/20
SCHEMBL180882 SCHEMBL180882 0.51 5/20
SCHEMBL226242 SCHEMBL226242 0.64 4/20

Clinical trials — most relevant to KCNE1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Effect of Methadone and Hydromorphone on the QT Interval After Anesthesia and Surgery PHASE4RECRUITING
Role of Eplerenone in Reducing Recurrence of Atrial Fibrillation in Patient With Structural Heart Disease PHASE4NOT_YET_RECRUITING
Safety and Efficacy Study Comparing Raltegravir to a Protease Inhibitor in Treatment-naïve, HIV/Hepatitis C Drug Users PHASE4UNKNOWN
Cortical Excitability Changes Induced by Retigabine: a Transcranial Magnetic Stimulation Study PHASE3COMPLETED
Mutation-specific Therapy for the Long QT Syndrome PHASE2COMPLETED
A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy PHASE1/PHASE2RECRUITING
Long-term Efficacy Study of Sodium Channel Blocker in LQT3 Patients PHASE2COMPLETED
N-of-1 in ATS and MEPPC PHASE2NOT_YET_RECRUITING
Sandostatine® LP and Hyperinsulinism PHASE2COMPLETED
Safety, Blood Levels and Effects of AUT00201 in Patients With MEAK PHASE1COMPLETED
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients. nanUNKNOWN
The Physiological Effects of Human Ether-a-go-go-Related Gene (hERG)Blockade on Metabolism nanCOMPLETED
A Cohort Study on the Prognosis of Neonatal KCNQ2 Gene-associated Epileptic Encephalopathy nanUNKNOWN
Genetic Determinants of Sudden Cardiac Death nanCOMPLETED
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives nanUNKNOWN
Qatar Cardiovascular Biorepository of AF Patients nanUNKNOWN
Genetic and Biohumoral Factors Involved in Menière's Disease and Their Correlation With Phenotypes nanRECRUITING
Characteristics of Episodic Ataxia Syndrome nanCOMPLETED
The Effects of the Anti Nausea Drugs Droperidol and Ondansetron on the Way the Heart Recovers Between Beats nanCOMPLETED
The Effects of the Anesthetic Drug Propofol on the Way the Heart Recovers Between Beats nanCOMPLETED
Comparison Between Epinephrine and Exercise Test in QT Long Syndrome Patients nanUNKNOWN
Development of an Artificial Intelligence Algorithm to Detect Pathological Repolarization Disorders on the ECG and the Risk of Ventricular Arrhythmias nanRECRUITING
Clinical Phenotype and Omics Study of KCNQ2-related Epilepsy nanUNKNOWN
Metabolism of Patients With Genetically Caused Cardiac Arrhythmia nanUNKNOWN
Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA) nanUNKNOWN
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain. nanUNKNOWN
Characteristics of Andersen-Tawil Syndrome nanCOMPLETED
Building of a Diagnostic/Prognostic Database for Human ERG Variant Effects nanRECRUITING
Interaction of Potassium and Genetic Risk Variants on Diabetes Risk nanCOMPLETED
Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a KCNE1 binder may also engage these)

ProteinNameSimilarity
Q5R8Q2 — 1.000 Q5R8Q2 →
Q9XSP1 — 1.000 Q9XSP1 →
Q60409 — 1.000 Q60409 →
P23299 — 0.996 P23299 →
P15383 — 0.995 P15383 →
Q9TUH9 — 0.991 Q9TUH9 →
Q28705 — 0.987 Q28705 →
A8MWV9 — 0.974 A8MWV9 →
P63161 — 0.971 P63161 →
Q9Y6J6 — 0.967 Q9Y6J6 →
Q9D808 — 0.967 Q9D808 →
P63160 — 0.967 P63160 →
O73698 — 0.967 O73698 →
Q08CB3 — 0.966 Q08CB3 →
Q76HP2 — 0.964 Q76HP2 →
Q8CB65 — 0.962 Q8CB65 →
P0C8N6 — 0.961 P0C8N6 →
Q9NWR8 — 0.960 Q9NWR8 →
Q8CHT6 — 0.960 Q8CHT6 →
Q5ZJY9 — 0.960 Q5ZJY9 →
Q9BCZ4 — 0.960 Q9BCZ4 →
Q91WM6 — 0.960 Q91WM6 →
Q14C87 — 0.959 Q14C87 →
O76095 — 0.959 O76095 →
Q76HP3 — 0.959 Q76HP3 →
K7EJ46 — 0.959 K7EJ46 →
Q6ZQE4 — 0.958 Q6ZQE4 →
A7MBC7 — 0.958 A7MBC7 →
J3QMI4 — 0.958 J3QMI4 →
O88823 — 0.958 O88823 →