Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.77 |
| ▸ | MEN1 | O00255 | 8/20 | 0.77 |
| ▸ | GAA | P10253 | 8/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.77 |
| ▸ | HPGD | P15428 | 2/20 | 0.77 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.77 |
| ▸ | NPC1 | O15118 | 6/20 | 0.74 |
| ▸ | RAB9A | P51151 | 6/20 | 0.74 |
| ▸ | POLB | P06746 | 6/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.60 |
| ▸ | PKM | P14618 | 2/20 | 0.60 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29518135 | 0.94 | MAPT (0.77) | MAPTKMT2AKDM4EMEN1GAA | |
| SCHEMBL29518137 | 0.94 | MAPT (0.77) | MAPTKMT2AKDM4EMEN1GAA | |
| SCHEMBL12113861 | 0.94 | GAA (0.87) | MAPTKMT2AKDM4EMEN1GAA | |
| SCHEMBL28369669 | 0.76 | PHGDH (0.69) | MAPTKMT2AKDM4EMEN1GAA | |
| SCHEMBL28369671 | 0.76 | PHGDH (0.69) | MAPTKMT2AKDM4EMEN1GAA | |
| SCHEMBL20115633 | 0.75 | PHGDH (0.85) | MAPTKMT2AKDM4EMEN1GAA | |
| SCHEMBL21292833 | 0.75 | PHGDH (0.85) | MAPTKMT2AKDM4EMEN1GAA | |
| SCHEMBL6422197 | 0.74 | KDM4E (0.62) | MAPTKMT2AKDM4EMEN1GAA | |
| SCHEMBL6422200 | 0.74 | KDM4E (0.62) | MAPTKMT2AKDM4EMEN1GAA | |
| SCHEMBL6721163 | 0.74 | ALDH1A1 (0.75) | MAPTKMT2AKDM4EMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053477-B2 | Including but hot limited to pentamidine and derivatives thereof | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2011-11-08 | — | — | US | disclosed |