Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | IGLV6-57 | P01721 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10038198 | 0.83 | KDM4E (0.57) | NFKB1KDM4EHSD17B10GLAHPGD | |
| SCHEMBL10038278 | 0.81 | NFKB1 (0.64) | NFKB1KDM4EGLAHPGDMAPK1 | |
| SCHEMBL10038276 | 0.75 | KDM4E (0.47) | NFKB1KDM4EHSD17B10GLAHPGD | |
| SCHEMBL25392395 | 0.74 | NFKB1 (0.56) | NFKB1KDM4EHSD17B10GLAHPGD | |
| SCHEMBL31036840 | 0.74 | NFKB1 (0.48) | NFKB1KDM4EHSD17B10GLAHPGD | |
| SCHEMBL10038137 | 0.74 | NFKB1 (0.66) | NFKB1KDM4EGLAHPGDMAPK1 | |
| SCHEMBL10038234 | 0.73 | NFKB1 (0.65) | NFKB1KDM4EGLAHPGDMAPK1 | |
| SCHEMBL10038099 | 0.73 | NFKB1 (0.65) | NFKB1KDM4EHPGDMAPK1RAB9A | |
| SCHEMBL25392551 | 0.73 | KDM4E (0.52) | NFKB1KDM4EHSD17B10GLAHPGD | |
| SCHEMBL10038287 | 0.73 | NFKB1 (0.64) | NFKB1KDM4EHPGDMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058427-B2 | Coumarin compounds and their use for treating cancer | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2011-11-15 | — | — | US | disclosed |
| US-8058427-B2 | Coumarin compounds and their use for treating cancer | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2011-11-15 | — | — | US | disclosed |
| US-20090312317-A1 | COUMARIN COMPOUNDS AND THEIR USE FOR TREATING CANCER | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-12-17 | — | — | US | disclosed |
| US-20090312317-A1 | COUMARIN COMPOUNDS AND THEIR USE FOR TREATING CANCER | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312317-A1 | COUMARIN COMPOUNDS AND THEIR USE FOR TREATING CANCER | SIRT3, CBR3, RDX | NFKB1 1563/4885KDM4E 2566/4885HSD17B10 538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.