Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14419996 | 0.87 | CCR1 (0.43) | CCR1CHRM2CCR5 | |
| SCHEMBL14420171 | 0.83 | CCR1 (0.40) | CCR1CHRM2CCR5 | |
| SCHEMBL13824452 | 0.83 | CCR1 (0.42) | CCR1CHRM2CCR5 | |
| SCHEMBL14420040 | 0.82 | CCR1 (0.41) | CCR1CHRM2CCR5 | |
| SCHEMBL15478413 | 0.81 | CCR1 (0.64) | CCR1CHRM2CCR5CARM1PRMT6 | |
| SCHEMBL656560 | 0.81 | CCR1 (0.64) | CCR1CHRM2CCR5CARM1PRMT6 | |
| SCHEMBL654987 | 0.81 | CCR1 (0.64) | CCR1CHRM2CCR5CARM1PRMT6 | |
| SCHEMBL656561 | 0.81 | CCR1 (0.64) | CCR1CHRM2CCR5CARM1PRMT6 | |
| SCHEMBL654986 | 0.81 | CCR1 (0.64) | CCR1CHRM2CCR5CARM1PRMT6 | |
| SCHEMBL15478384 | 0.81 | CCR1 (0.64) | CCR1CHRM2CCR5CARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058287-B2 | Chemokine receptor antagonists and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-11-15 | — | — | US | disclosed |