Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14580315 | 0.94 | MAPK1 (0.39) | CCR1CHRM2CCR5MAPK1 | |
| SCHEMBL10288005 | 0.90 | CCR1 (0.42) | CCR1CHRM2CCR5DRD2DRD4 | |
| SCHEMBL12121694 | 0.90 | CCR1 (0.40) | CCR1CHRM2CCR5DRD2DRD4 | |
| SCHEMBL10287644 | 0.88 | CCR1 (0.41) | CCR1CHRM2CCR5DRD2DRD4 | |
| SCHEMBL14419996 | 0.83 | CCR1 (0.43) | CCR1CHRM2CCR5 | |
| SCHEMBL14420040 | 0.83 | CCR1 (0.41) | CCR1CHRM2CCR5 | |
| SCHEMBL12121697 | 0.83 | CCR1 (0.43) | CCR1CHRM2CCR5 | |
| SCHEMBL10287640 | 0.80 | CCR1 (0.66) | CCR1CHRM2CCR5DRD2DRD4 | |
| SCHEMBL654944 | 0.80 | CCR1 (0.66) | CCR1CHRM2CCR5DRD2DRD4 | |
| SCHEMBL10287634 | 0.80 | CCR1 (0.66) | CCR1CHRM2CCR5DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541365-B2 | Chemokine receptor antagonists and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-06-02 | — | — | US | disclosed |