Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.31 |
| ▸ | VEGFA | P15692 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1344605 | 0.93 | CYP3A4 (0.48) | CYP3A4CYP2C9CYP2C19EPAS1PDCD1 | |
| SCHEMBL5377301 | 0.90 | CYP3A4 (0.38) | CYP3A4CYP2C9CYP2C19EPAS1PDCD1 | |
| SCHEMBL1343942 | 0.90 | CYP3A4 (0.47) | CYP3A4CYP2C9CYP2C19EPAS1PDCD1 | |
| SCHEMBL12132023 | 0.88 | CYP3A4 (0.45) | CYP3A4CYP2C9CYP2C19EPAS1PDCD1 | |
| SCHEMBL1343524 | 0.88 | CYP3A4 (0.58) | CYP3A4CYP2C9CYP2C19EPAS1KCNH2 | |
| SCHEMBL5372331 | 0.87 | MAPT (0.35) | CYP3A4CYP2C9CYP2C19EPAS1MAPT | |
| SCHEMBL1344213 | 0.86 | CYP3A4 (0.39) | CYP3A4CYP2C9CYP2C19EPAS1PDCD1 | |
| SCHEMBL12130346 | 0.86 | TP53 (0.35) | CYP3A4CYP2C19F10TP53MAPT | |
| SCHEMBL1344436 | 0.86 | CYP3A4 (0.44) | CYP3A4CYP2C9CYP2C19EPAS1PDCD1 | |
| SCHEMBL1343934 | 0.85 | CYP3A4 (0.41) | CYP3A4CYP2C9CYP2C19EPAS1PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063064-B2 | Non-nucleoside reverse transcriptase inhibitors | ROCHE PALO ALTO LLC (US) | 2011-11-22 | — | — | US | disclosed |
| US-20110059975-A1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | KENNEDY-SMITH JOSHUA | 2011-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059975-A1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | RPIA, ADORA2B, NQO2 | CYP3A4 269/4885CYP2C9 1346/4885CYP2C19 1214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.