Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 10/20 | 0.43 |
| ▸ | ACACA | Q13085 | 10/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.31 |
| ▸ | MST1R | Q04912 | 1/20 | 0.31 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.31 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.31 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12134155 | 0.95 | ACACB (0.43) | ACACBACACAHDAC1HDAC2ABL1 | |
| SCHEMBL12134150 | 0.88 | HDAC1 (0.33) | ACACBACACAHDAC1HDAC2JAK2 | |
| SCHEMBL10207868 | 0.85 | ACACB (0.44) | ACACBACACAHDAC1HDAC2EDNRB | |
| SCHEMBL12134145 | 0.84 | RORC (0.35) | MAOBALDH1A1 | |
| SCHEMBL12134153 | 0.82 | HDAC1 (0.36) | ACACBACACAHDAC1HDAC2JAK2 | |
| SCHEMBL10207888 | 0.81 | ACACB (0.44) | ACACBACACAHDAC1HDAC2EDNRB | |
| SCHEMBL468674 | 0.81 | ACACB (0.47) | ACACBACACAABL1JAK2NTRK1 | |
| SCHEMBL10207881 | 0.81 | ACACB (0.43) | ACACBACACAHDAC1HDAC2KDM1A | |
| SCHEMBL10207938 | 0.80 | ACACB (0.39) | ACACBACACAHDAC1HDAC2KDM1A | |
| SCHEMBL2355425 | 0.79 | ACACB (0.46) | ACACBACACAABL1JAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8536351-B2 | 2-aryl-5-heterocyclyl-cyclohexane-1,3,dione compounds and their use as herbicides | SYNGENTA CROP PROTECTION LLC (US) | 2013-09-17 | — | — | US | disclosed |
| US-8536351-B2 | 2-aryl-5-heterocyclyl-cyclohexane-1,3,dione compounds and their use as herbicides | SYNGENTA CROP PROTECTION LLC (US) | 2013-09-17 | — | — | US | disclosed |
| US-20110281930-A1 | Use of 2-Aryl-5-heterocyclyl-cyclohexane-1,3-dione Compounds as Insecticides, Acaricides, and/ or Fungicides | BAYER CROPSCIENCE AG (DE) | 2011-11-17 | — | — | US | disclosed |
| US-20110281930-A1 | Use of 2-Aryl-5-heterocyclyl-cyclohexane-1,3-dione Compounds as Insecticides, Acaricides, and/ or Fungicides | BAYER CROPSCIENCE AG (DE) | 2011-11-17 | — | — | US | disclosed |
| EP-2134699-B1 | 2-ARYL-5-HETEROCYCLYL-CYCLOHEXANE-1,3-DIONE COMPOUNDS AND THEIR USE AS HERBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010081687-A1 | USE OF 2-ARYL-5-HETEROCYCLYL-CYCLOHEXANE-L,3-DIONE COMPOUNDS AS INSECTICIDES, ACARICIDES AND / OR FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2010-07-22 | — | — | WO | disclosed |
| US-20100113270-A1 | 2-ARYL-5-HETEROCYCLYL-CYCLOHEXANE-1,3,DIONE COMPOUNDS AND THEIR USE AS HERBICIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-05-06 | — | — | US | disclosed |
| US-20100113270-A1 | 2-ARYL-5-HETEROCYCLYL-CYCLOHEXANE-1,3,DIONE COMPOUNDS AND THEIR USE AS HERBICIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113270-A1 | 2-ARYL-5-HETEROCYCLYL-CYCLOHEXANE-1,3,DIONE COMPOUNDS AND THEIR USE AS HERBICIDES | C3AR1, C5, C9 | ACACB 2438/4885ACACA 2767/4885HDAC1 2397/4885 |
| US-20110281930-A1 | Use of 2-Aryl-5-heterocyclyl-cyclohexane-1,3-dione Compounds as Insecticides, Acaricides, and/ or Fungicides | DDT, CYP1B1, CYP1A1 | ACACB 790/4885ACACA 299/4885HDAC1 188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.