Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 12/20 | 0.65 |
| ▸ | ESR1 | P03372 | 13/20 | 0.64 |
| ▸ | ESR2 | Q92731 | 10/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.64 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | PLD2 | O14939 | 1/20 | 0.61 |
| ▸ | ESRRB | O95718 | 1/20 | 0.61 |
| ▸ | PGR | P06401 | 1/20 | 0.61 |
| ▸ | ESRRG | P62508 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12134466 | 0.89 | CYP19A1 (0.67) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL12134462 | 0.86 | PTGS2 (0.51) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL17787470 | 0.85 | CYP19A1 (0.77) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL23851301 | 0.82 | CYP19A1 (0.69) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL23851300 | 0.82 | CYP19A1 (0.69) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL12468690 | 0.80 | CYP19A1 (0.73) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL16233656 | 0.80 | CYP19A1 (0.82) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL641723 | 0.80 | CYP19A1 (0.73) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL18291054 | 0.80 | ESR1 (0.82) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL641722 | 0.80 | CYP19A1 (0.73) | CYP19A1ESR1ESR2CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063249-B1 | Substituted triphenyl butenes | OLEMA PHARMACEUTICALS, INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-8063249-B1 | Substituted triphenyl butenes | OLEMA PHARMACEUTICALS, INC. (US) | 2011-11-22 | — | — | US | disclosed |